ID   MCMBP_DICDI             Reviewed;         719 AA.
AC   Q55CZ6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Mini-chromosome maintenance complex-binding protein;
DE            Short=MCM-BP;
DE            Short=MCM-binding protein;
GN   Name=mcmbp; ORFNames=DDB_G0270664;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Associated component of the MCM complex that acts as a
CC       regulator of DNA replication. Binds to the MCM complex during late S
CC       phase and may act by promoting the disassembly of the MCM complex from
CC       chromatin (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the MCM complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MCMBP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000005; EAL72682.1; -; Genomic_DNA.
DR   RefSeq; XP_646335.1; XM_641243.1.
DR   AlphaFoldDB; Q55CZ6; -.
DR   STRING; 44689.DDB0266859; -.
DR   PaxDb; Q55CZ6; -.
DR   EnsemblProtists; EAL72682; EAL72682; DDB_G0270664.
DR   GeneID; 8617290; -.
DR   KEGG; ddi:DDB_G0270664; -.
DR   dictyBase; DDB_G0270664; -.
DR   eggNOG; KOG2545; Eukaryota.
DR   HOGENOM; CLU_029811_0_0_1; -.
DR   InParanoid; Q55CZ6; -.
DR   OMA; QMANCLT; -.
DR   PhylomeDB; Q55CZ6; -.
DR   PRO; PR:Q55CZ6; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   InterPro; IPR019140; MCM_complex-bd.
DR   PANTHER; PTHR13489; PTHR13489; 1.
DR   Pfam; PF09739; MCM_bind; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA replication; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..719
FT                   /note="Mini-chromosome maintenance complex-binding protein"
FT                   /id="PRO_0000328427"
FT   REGION          152..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   719 AA;  82930 MW;  1706221E8B35C3C9 CRC64;
     MTDNNNLDSL IIDKDEYLNS PMNVVDKLFK FDQNNLNNGT VYKKFENVIS EDQIYKSIPL
     VSTINQCDLN SGKLVKIRCM IQDIFDPQFC PSFNKIKNIE TNEIRLEASK YKDKINLNDC
     EELIFDSFDS STFDKTILYC IPIPCENKWV NNNNNNNNNN NNNNNNNNNN NNNNGNEQIS
     SSLLNKKKRN IDDADMKNEN DEENKKSKDQ KSTTTTTTTT SKEGEEEGEE GEQLTKSKKL
     LTNNKIDINK IFNYPIPIDS NDENNLKTPF IVNIYDDDII FDENNKAVTF KINEIIEFVG
     VVAKFNPTLQ HQSSNSSDQG ETTTTIIDLM SMLDVDEIST IPDTLIPQFH AITYRYLDPY
     KFNHLNPFSI DTNTTINNNN NNNNNNNNNN NNNNNNNNNN NNNNNNPNNN NPNNNNLNNN
     LIRNELIKFI KLFIVDELLS EYLLFHLISK VYSFTSGLSI GNFSMNISIP NDKEFQRLPQ
     LIELLYEILL ARSYRFSMSL ENLNDMDVVP YKDYDRNRIV SGLLQLPKGT NLILDETQLT
     EGKVESQGIK VLNALNTLSI QQKVEYDFKY HPIEIQTDLP TISISFGKSL IKGTTQISIN
     KSIQLPTINE INQQLIHSYN NDKLNQFRNY INHCKNLSFK ISSPTTTTIA ESDDATRHIQ
     EDFVKSRQLD SKMTTDVFHY WLTLSRLVAL SFNDQYIKID KWNIMKSLEE KRKLTINNL