ID   MCMBP_SALSA             Reviewed;         626 AA.
AC   B5DG51;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Mini-chromosome maintenance complex-binding protein;
DE            Short=MCM-BP;
DE            Short=MCM-binding protein;
GN   Name=mcmbp;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=White muscle;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Associated component of the mcm complex that acts as a
CC       regulator of DNA replication. Binds to the MCM complex during late S
CC       phase and promotes the disassembly of the mcm complex from chromatin,
CC       thereby acting as a key regulator of pre-replication complex (pre-RC)
CC       unloading from replicated DNA. Can dissociate the mcm complex without
CC       addition of ATP; probably acts by destabilizing interactions of each
CC       individual subunits of the mcm complex. Required for sister chromatid
CC       cohesion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the mcm complex: associates with the mcm3-7
CC       complex which lacks mcm2, while it does not interact with the mcm
CC       complex when mcm2 is present (mcm2-7 complex). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Associates with
CC       chromatin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MCMBP family. {ECO:0000305}.
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DR   EMBL; BT043610; ACH70725.1; -; mRNA.
DR   RefSeq; NP_001135159.1; NM_001141687.1.
DR   AlphaFoldDB; B5DG51; -.
DR   STRING; 8030.ENSSSAP00000043894; -.
DR   GeneID; 100196658; -.
DR   KEGG; sasa:100196658; -.
DR   CTD; 79892; -.
DR   OrthoDB; 1011739at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa18.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; ISS:UniProtKB.
DR   GO; GO:0007062; P:sister chromatid cohesion; ISS:UniProtKB.
DR   InterPro; IPR019140; MCM_complex-bd.
DR   PANTHER; PTHR13489; PTHR13489; 1.
DR   Pfam; PF09739; MCM_bind; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; DNA replication; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..626
FT                   /note="Mini-chromosome maintenance complex-binding protein"
FT                   /id="PRO_0000405810"
FT   REGION          152..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..211
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   626 AA;  70816 MW;  02E7B7649C31A283 CRC64;
     MPSSHDWINK PLGVVEAMFA QNNSNPEWEE KVLEYFRGQL KEKESLSWVP SLNDVPLHYL
     KPNSLVKFRC LVQDMFDPEF YMGVYETVDP STKTNVLRCG KYKDVTECGV DLNSRNTVTA
     ERQTFYCVPI PGESPWAKES YGCSSQARVV PSTSYVPSRQ KRSYEEDDDD MDTQPQKQRE
     PHTEPHGNGD SKRQETEAPS SQTTAPSDCS SHLDLNFPLP GERGPACLVK VYEGLDSFKL
     NDTLEIYGIL SVNPVLTVLG EEKDPSSLLL NPSESMESPE EQRAHDPPAS LVPRLHMLYA
     RPLQHNNPLL PSAPTEDHSA FVSSFLVEMA SVRAELLAYL THVLLGDGLA AEYLLLHLIS
     NVYTRRDVLP LGKFTLNLSG CPLNSYTERL YQIIQQLVPC SYRLSMSLHT MNSMRLVPKK
     DYVANRLVSG ALQLARNTSL FLDETQLEQG QLDSSGVRNI TALGNLISWQ KVDYDFSYHQ
     MEFPCNINVL VTSEGRSLLP SDCQVPLQPQ VTPPNMEEYL TTIHMAQFTS QMNKFRVYLS
     LARTLDYSIS DEVTKAVEDD FVDMRKDDPQ SVTAEDLHRM LVVARLLSLS MGQTTLSRDG
     WMRAKHIDML RRSRTEQQKS LNSNEP