ID   MCMBP_XENTR             Reviewed;         627 AA.
AC   Q28DV7; Q66JB9;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Mini-chromosome maintenance complex-binding protein;
DE            Short=MCM-BP;
DE            Short=MCM-binding protein;
GN   Name=mcmbp; ORFNames=TEgg098e22.1-001;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associated component of the mcm complex that acts as a
CC       regulator of DNA replication. Binds to the MCM complex during late S
CC       phase and promotes the disassembly of the mcm complex from chromatin,
CC       thereby acting as a key regulator of pre-replication complex (pre-RC)
CC       unloading from replicated DNA. Can dissociate the mcm complex without
CC       addition of ATP; probably acts by destabilizing interactions of each
CC       individual subunits of the mcm complex. Required for sister chromatid
CC       cohesion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the mcm complex: associates with the mcm3-7
CC       complex which lacks mcm2, while it does not interact with the mcm
CC       complex when mcm2 is present (mcm2-7 complex). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Associates with
CC       chromatin. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q28DV7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q28DV7-2; Sequence=VSP_040722;
CC   -!- SIMILARITY: Belongs to the MCMBP family. {ECO:0000305}.
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DR   EMBL; CR848576; CAJ81286.1; -; mRNA.
DR   EMBL; BC080982; AAH80982.1; -; mRNA.
DR   RefSeq; NP_001008083.1; NM_001008082.1. [Q28DV7-1]
DR   AlphaFoldDB; Q28DV7; -.
DR   STRING; 8364.ENSXETP00000061252; -.
DR   PRIDE; Q28DV7; -.
DR   DNASU; 493445; -.
DR   GeneID; 493445; -.
DR   KEGG; xtr:493445; -.
DR   CTD; 79892; -.
DR   Xenbase; XB-GENE-5897999; mcmbp.
DR   eggNOG; KOG2545; Eukaryota.
DR   InParanoid; Q28DV7; -.
DR   OrthoDB; 1011739at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000010237; Expressed in testis and 28 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; ISS:UniProtKB.
DR   GO; GO:0007062; P:sister chromatid cohesion; ISS:UniProtKB.
DR   InterPro; IPR019140; MCM_complex-bd.
DR   PANTHER; PTHR13489; PTHR13489; 1.
DR   Pfam; PF09739; MCM_bind; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell cycle; Cell division; DNA replication; Mitosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..627
FT                   /note="Mini-chromosome maintenance complex-binding protein"
FT                   /id="PRO_0000405812"
FT   REGION          166..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         20
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_040722"
FT   CONFLICT        45
FT                   /note="D -> N (in Ref. 1; CAJ81286)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        48
FT                   /note="A -> T (in Ref. 1; CAJ81286)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        235
FT                   /note="L -> R (in Ref. 1; CAJ81286)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        390
FT                   /note="L -> I (in Ref. 1; CAJ81286)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   627 AA;  70113 MW;  FD827E92B2FDEA3D CRC64;
     MTGGESWISD PLGVVQGLFA AQRPADGDWQ KNVTDYFSAK LRDSDSAAAV PCLNDTPLHY
     LKPNSLVRFR CMVQDMFDPE FYMGVYETVD TNTSARVLHF GKYRDVAESL PQQEVDPDSR
     RNVTCERQTF YCVPVPGECP WVKDAYTSCS QAKVCASTSY APSRQKRSYE EDEDAAPCDT
     RASHGLGEPK RLETEAAGAQ QHLPSSCSSA PDLNFPLPGE KGPACLIKVY EGWDLFKVND
     VLEVYGILSV DPALSALTED REAVSALLDP SDDMDTLEEH RAHCPPASLV PRIHTIVTRK
     LQHNNPLLPP SLQGSEESKL FVSNFLSELS AVRAELLDFL SHALLGDSLA AEYLILHLIS
     TVYARRDVLP LGKFTLNLSG CPRNGTFSEL LYRVVQQLVP AAHYLPMTIE NMNKLCFIPR
     KDYNANRLVS GLLQLSPQTS LLVDETLLEQ GQLDTTGVHN VTALGNLITW QKVDYDFSYH
     RMEFPCNINV LVTSEGRSLL PSDCHVHLQP QMMPPNLEQY LGALLAASLP SLLNKFRTYI
     GLLRLLDYSI SDEATKAVED DFVEMRKNDP QSISADDLHR LLVVARLSSL SAGQTSLSRE
     QWLRAKQLEQ QRKNRLREQK HMNVNEL