ID   MCMD2_RAT               Reviewed;         681 AA.
AC   Q5XI14;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Minichromosome maintenance domain-containing protein 2;
DE            Short=MCM domain-containing protein 2;
GN   Name=Mcmdc2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays an important role in meiotic recombination and
CC       associated DNA double-strand break repair.
CC       {ECO:0000250|UniProtKB:E9Q956}.
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DR   EMBL; BC083882; AAH83882.1; -; mRNA.
DR   RefSeq; NP_001019511.2; NM_001024340.1.
DR   AlphaFoldDB; Q5XI14; -.
DR   SMR; Q5XI14; -.
DR   STRING; 10116.ENSRNOP00000037494; -.
DR   iPTMnet; Q5XI14; -.
DR   PhosphoSitePlus; Q5XI14; -.
DR   PaxDb; Q5XI14; -.
DR   GeneID; 500392; -.
DR   KEGG; rno:500392; -.
DR   UCSC; RGD:1561068; rat.
DR   CTD; 157777; -.
DR   RGD; 1561068; Mcmdc2.
DR   eggNOG; KOG0480; Eukaryota.
DR   InParanoid; Q5XI14; -.
DR   OrthoDB; 736394at2759; -.
DR   PhylomeDB; Q5XI14; -.
DR   TreeFam; TF332272; -.
DR   PRO; PR:Q5XI14; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR   GO; GO:1990918; P:double-strand break repair involved in meiotic recombination; ISO:RGD.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:0042140; P:late meiotic recombination nodule assembly; ISO:RGD.
DR   GO; GO:0007146; P:meiotic recombination nodule assembly; ISO:RGD.
DR   GO; GO:0048477; P:oogenesis; ISO:RGD.
DR   GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR   GO; GO:0007130; P:synaptonemal complex assembly; ISO:RGD.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031327; MCM.
DR   InterPro; IPR041562; MCM_lid.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11630; PTHR11630; 1.
DR   Pfam; PF17855; MCM_lid; 1.
DR   SMART; SM00350; MCM; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Meiosis; Phosphoprotein; Reference proteome.
FT   CHAIN           1..681
FT                   /note="Minichromosome maintenance domain-containing protein
FT                   2"
FT                   /id="PRO_0000255259"
FT   DOMAIN          533..621
FT                   /note="MCM"
FT   MOD_RES         292
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4G0Z9"
SQ   SEQUENCE   681 AA;  76063 MW;  76D52C985A5F0794 CRC64;
     MGKLPMKEAA LVYLDRSGGL QKFMDDCKYY NDSKQSYAVY RFSILINPCD VVELDAELGN
     HILHHPLKAA QVFQSVCFVA VKTLSLIGKL QTETQINIVL KLTHLPSLPS YSLDLCEFPL
     NYASQRFYMM QGIVIAMTTV TKYTQGARFL CSDEVCPFSK GFQYIRVHVP GATESATVRN
     DFLCRLCSSS LQEDRKFRVL GDKQIIEIIT TKVLHAFQGD PKNQPFRFQS LSVFLRDELV
     NKMKIGNEYK IIGIPVCVKT SQTALCVEAN SITPYTAKVP SGISDNFRCL LSLTSSSCWR
     FTAILANVFA SHIVPLGTYN LLKLCLLMSL VQTRDCSSER ENCLDILVIT SDTLLVDRLL
     NFSMNLVSRG IRHPVCTEVF PTVSRDKYGT GAVSIQAGSA LLARGGVCFI GDLTSHKKDK
     LEQLQSALES RSVTVFIPGK KFGDDFDQQM TFPIQCSFWS FVDMDSSSRR NVQKASTLIG
     QMDCSLIPAN LAEAFGLLVN CKESSPCHPL LPTVQHTLKK AVDPKGPPYL ASKQFTTEDF
     EKLLAFAKNL NVEFSLEAER MIHGYYLASR RIRTDSIHGS KLSANALKYL VSLSEAHARL
     NLRNKVLRED VLIAALLFEI SLTLKYGATA FCVAPNALFP FELYDEDYLE QRDLYLTQCQ
     QQLQHFIATC GPGTAVLSSD E