ID   MCP1_THEMA              Reviewed;         656 AA.
AC   Q9WYR0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Methyl-accepting chemotaxis protein 1;
GN   Name=mcp1; OrderedLocusNames=TM_0429;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
RN   [2]
RP   METHYLATION AT GLU-401; GLU-407; GLU-590 AND GLU-596.
RX   PubMed=16707700; DOI=10.1128/jb.00181-06;
RA   Perez E., Zheng H., Stock A.M.;
RT   "Identification of methylation sites in Thermotoga maritima chemotaxis
RT   receptors.";
RL   J. Bacteriol. 188:4093-4100(2006).
CC   -!- FUNCTION: Chemotactic-signal transducers respond to changes in the
CC       concentration of attractants and repellents in the environment,
CC       transduce a signal from the outside to the inside of the cell, and
CC       facilitate sensory adaptation through the variation of the level of
CC       methylation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; AE000512; AAD35514.1; -; Genomic_DNA.
DR   PIR; E72379; E72379.
DR   RefSeq; NP_228239.1; NC_000853.1.
DR   RefSeq; WP_010865116.1; NZ_CP011107.1.
DR   AlphaFoldDB; Q9WYR0; -.
DR   SMR; Q9WYR0; -.
DR   STRING; 243274.THEMA_02580; -.
DR   PRIDE; Q9WYR0; -.
DR   EnsemblBacteria; AAD35514; AAD35514; TM_0429.
DR   KEGG; tma:TM0429; -.
DR   eggNOG; COG0840; Bacteria.
DR   InParanoid; Q9WYR0; -.
DR   OMA; QTITAMT; -.
DR   OrthoDB; 477199at2; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   Pfam; PF00015; MCPsignal; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Chemotaxis; Membrane; Methylation; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..656
FT                   /note="Methyl-accepting chemotaxis protein 1"
FT                   /id="PRO_0000250993"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          299..351
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          370..606
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   MOD_RES         401
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000269|PubMed:16707700"
FT   MOD_RES         407
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000269|PubMed:16707700"
FT   MOD_RES         590
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000269|PubMed:16707700"
FT   MOD_RES         596
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000269|PubMed:16707700"
SQ   SEQUENCE   656 AA;  72217 MW;  EB932E2C3505B143 CRC64;
     MSLRKKVFLL MIVVVAGLLL SFFLIYRSVS NSIINSVRSN TENQAKALSK FVVEKLNNVT
     NVARSAATYL GSQFFEAYMI TNQLKTTVEK EKSTFAFAFS ALSFNKSAAL TDGNRVDRVD
     FADYEKYIKA VEGKDIFFMP ETFQGTPVLT VVVPIETMNT RTGIVGFGIN LSENSDLWKA
     VVEEGKASKS GYGLLVTSDG KVLIHKDMGN FMKDVKELGG FEKAFEEAKS GGEKYVEYEY
     NGEKKYTVWE KVPGYDFYIF STGYLEELLA EGRKATLGTI VTYVVFGGVI FAVLFVSMMP
     VVKRMRQQVE KVKRFGEGDL TVEFEAKGRD ELTQIEESLK EAALSLKEMI VSIIEAAKEL
     SGASEEIKVL SEESHKMSEN LHEEAKKILD EANNMSSALT EVTSGVEEVA ASAQNISKIT
     QDLTERSEAV TKAAREGTER VEAVGGVINK LKGSAERQRD YLRELVDSAK TIGEIVDTIS
     SIAEQTNLLA LNAAIEAARA GEAGRGFAVV ADEIRKLAEE SQRATEDIAK MLSSLRTTIE
     HVENGSKEMF EGVDEIAVMG EEVTKRFREI LGRIEEINSM IENTAATAQE QGAAAEEMAS
     AMDNVTKIVE GVVESLNRME SLIEDQTTSA AKVSQAAERL SELSEQLSTL VQKFKV