MCP2L_SCHPO
ID MCP2L_SCHPO Reviewed; 557 AA.
AC O60111;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=ABC1 family protein MCP2 homolog {ECO:0000250|UniProtKB:Q06567};
DE Flags: Precursor;
GN ORFNames=SPBC15C4.02 {ECO:0000312|PomBase:SPBC15C4.02};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- FUNCTION: Involved in mitochondrial lipid homeostasis.
CC {ECO:0000250|UniProtKB:Q06567}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q06567}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. ADCK protein
CC kinase family. {ECO:0000305}.
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DR EMBL; CU329671; CAA18893.2; -; Genomic_DNA.
DR PIR; T39472; T39472.
DR RefSeq; NP_595922.2; NM_001021830.2.
DR AlphaFoldDB; O60111; -.
DR SMR; O60111; -.
DR STRING; 4896.SPBC15C4.02.1; -.
DR MaxQB; O60111; -.
DR PaxDb; O60111; -.
DR EnsemblFungi; SPBC15C4.02.1; SPBC15C4.02.1:pep; SPBC15C4.02.
DR GeneID; 2539608; -.
DR KEGG; spo:SPBC15C4.02; -.
DR PomBase; SPBC15C4.02; -.
DR VEuPathDB; FungiDB:SPBC15C4.02; -.
DR eggNOG; KOG1235; Eukaryota.
DR HOGENOM; CLU_006533_2_5_1; -.
DR InParanoid; O60111; -.
DR OMA; PYVKGNS; -.
DR PRO; PR:O60111; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032592; C:integral component of mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0016301; F:kinase activity; ISM:PomBase.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IBA:GO_Central.
DR GO; GO:0055091; P:phospholipid homeostasis; ISO:PomBase.
DR CDD; cd13969; ADCK1-like; 1.
DR InterPro; IPR004147; ABC1_dom.
DR InterPro; IPR045307; ADCK1_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF03109; ABC1; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..33
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 34..557
FT /note="ABC1 family protein MCP2 homolog"
FT /id="PRO_0000310291"
FT TOPO_DOM 34..39
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q06567"
FT TRANSMEM 40..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..557
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q06567"
SQ SEQUENCE 557 AA; 64114 MW; E2C9B1662447630C CRC64;
MFSRFSWPRI TRCFRSYPKK KSSCISFTHH AREHTNFKKP AVVGASITLM ASVALVDFDP
VKHAGVSSKR AYRVVLAGFL CFSDYKKVLG SSYASEEERQ LALSECHLRC AERSLKVFEE
NGGIYIKIGQ HLSAMGYVIP KEWTNTMVKL QDRCPSTSLK DIDHLFRVDT GKGLDETFDE
FDPIALGVAS LAQVHKARLK DSDVWVAVKV QHPSVSLNSP LDLSMTRWVF KAIKTFFPDF
KLMWLADEIE RSLPQELDFT REAKNSIETK EHFAHLSTSL YVPEVMWSKP RILVMEYVAG
ARIDNLSFMD EHSISRDLVS VDICHIFNEM IFGKGGHLHC DPHGGNVLIR SKPKNSKSPR
NYEIVLLDHG LYRDIPHELQ VDYANMWLNI INFNEKNLKF YAKKVANVSD ENFPIFATAI
TGRPYKSLKS LPIGGPNHEE EQKKFISALQ KGGMLQSIIR LLSTMPRLTL LLMKTNDLVR
SLDENLKTKS GPEKLYLIMA RYCLRCVYDD KMDSLWNSRS FWVSKVFKGT YYRLSYLFSS
LKYTLAENYF YYKHMYL
