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MCP4_ECOLI
ID   MCP4_ECOLI              Reviewed;         533 AA.
AC   P07018; P76300;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 176.
DE   RecName: Full=Methyl-accepting chemotaxis protein IV;
DE            Short=MCP-IV;
DE   AltName: Full=Dipeptide chemoreceptor protein;
GN   Name=tap; OrderedLocusNames=b1885, JW1874;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6305515; DOI=10.1016/0092-8674(83)90442-7;
RA   Krikos A., Mutoh N., Boyd A., Simon M.I.;
RT   "Sensory transducers of E. coli are composed of discrete structural and
RT   functional domains.";
RL   Cell 33:615-622(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA   Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA   Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA   Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA   Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA   Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA   Horiuchi T.;
RT   "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 40.1-50.0 min region on the linkage map.";
RL   DNA Res. 3:379-392(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
RN   [6]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=22380631; DOI=10.1111/j.1365-2958.2012.08021.x;
RA   Li G., Young K.D.;
RT   "Isolation and identification of new inner membrane-associated proteins
RT   that localize to cell poles in Escherichia coli.";
RL   Mol. Microbiol. 84:276-295(2012).
CC   -!- FUNCTION: Mediates taxis toward dipeptides via an interaction with the
CC       periplasmic dipeptide-binding protein.
CC   -!- FUNCTION: Chemotactic-signal transducers respond to changes in the
CC       concentration of attractants and repellents in the environment,
CC       transduce a signal from the outside to the inside of the cell, and
CC       facilitate sensory adaptation through the variation of the level of
CC       methylation. Attractants increase the level of methylation while
CC       repellents decrease the level of methylation, the methyl groups are
CC       added by the methyltransferase CheR and removed by the methylesterase
CC       CheB.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:22380631}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:22380631}. Note=Found predominantly at cell poles.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; J01705; AAA23567.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC74955.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15701.1; -; Genomic_DNA.
DR   PIR; E64951; QRECM2.
DR   RefSeq; NP_416399.1; NC_000913.3.
DR   RefSeq; WP_000483239.1; NZ_LN832404.1.
DR   AlphaFoldDB; P07018; -.
DR   SMR; P07018; -.
DR   BioGRID; 4262072; 172.
DR   DIP; DIP-10955N; -.
DR   IntAct; P07018; 2.
DR   STRING; 511145.b1885; -.
DR   PaxDb; P07018; -.
DR   PRIDE; P07018; -.
DR   EnsemblBacteria; AAC74955; AAC74955; b1885.
DR   EnsemblBacteria; BAA15701; BAA15701; BAA15701.
DR   GeneID; 946397; -.
DR   KEGG; ecj:JW1874; -.
DR   KEGG; eco:b1885; -.
DR   PATRIC; fig|1411691.4.peg.362; -.
DR   EchoBASE; EB0980; -.
DR   eggNOG; COG0840; Bacteria.
DR   HOGENOM; CLU_000445_107_16_6; -.
DR   InParanoid; P07018; -.
DR   OMA; QATWLEN; -.
DR   PhylomeDB; P07018; -.
DR   BioCyc; EcoCyc:TAP-MON; -.
DR   PRO; PR:P07018; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IMP:EcoCyc.
DR   GO; GO:0006935; P:chemotaxis; IMP:EcoCyc.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   CDD; cd00181; Tar_Tsr_LBD; 1.
DR   InterPro; IPR035440; 4HB_MCP_dom_sf.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR004091; Chemotax_Me-accpt_rcpt_Me-site.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR003122; Tar_rcpt_lig-bd.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   Pfam; PF02203; TarH; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   SMART; SM00319; TarH; 1.
DR   SUPFAM; SSF47170; SSF47170; 1.
DR   PROSITE; PS00538; CHEMOTAXIS_TRANSDUC_1; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Chemotaxis; Membrane; Methylation;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..533
FT                   /note="Methyl-accepting chemotaxis protein IV"
FT                   /id="PRO_0000110541"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..188
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210..533
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          212..264
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          269..498
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   MOD_RES         293
FT                   /note="Glutamate methyl ester (Gln)"
FT                   /evidence="ECO:0000250|UniProtKB:P07017"
FT   MOD_RES         300
FT                   /note="Glutamate methyl ester (Gln)"
FT                   /evidence="ECO:0000250|UniProtKB:P05704"
FT   MOD_RES         307
FT                   /note="Glutamate methyl ester (Gln)"
FT                   /evidence="ECO:0000250|UniProtKB:P05704"
FT   MOD_RES         489
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000250|UniProtKB:P05704"
FT   CONFLICT        335
FT                   /note="A -> G (in Ref. 1; AAA23567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        503
FT                   /note="H -> R (in Ref. 1; AAA23567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        527..533
FT                   /note="QIAPVVS -> TNCASGILK (in Ref. 1; AAA23567)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   533 AA;  57512 MW;  632570BE1E45DA38 CRC64;
     MFNRIRISTT LFLILILCGI LQIGSNGMSF WAFRDDLQRL NQVEQSNQQR AALAQTRAVM
     LQASTALNKA GTLTALSYPA DDIKTLMTTA RASLTQSTTL FKSFMAMTAG NEHVRGLQKE
     TEKSFARWHN DLEHQATWLE SNQLSDFLTA PVQGSQNAFD VNFEAWQLEI NHVLEAASAQ
     SQRNYQISAL VFISMIIVAA IYISSALWWT RKMIVQPLAI IGSHFDSIAA GNLARPIAVY
     GRNEITAIFA SLKTMQQALR GTVSDVRKGS QEMHIGIAEI VAGNNDLSSR TEQQAASLAQ
     TAASMEQLTA TVGQNADNAR QASELAKNAA TTAQAGGVQV STMTHTMQEI ATSSQKIGDI
     ISVIDGIAFQ TNILALNAAV EAARAGEQGR GFAVVAGEVR NLASRSAQAA KEIKGLIEES
     VNRVQQGSKL VNNAAATMID IVSSVTRVND IMGEIASASE EQQRGIEQVA QAVSQMDQVT
     QQNASLVEEA AVATEQLANQ ADHLSSRVAV FTLEEHEVAR HESVQLQIAP VVS
 
 
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