ID   MCP4_SCHPO              Reviewed;         355 AA.
AC   O14323;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Meiotic coiled-coil protein 4;
DE   AltName: Full=Meiotically up-regulated gene 101 protein;
GN   Name=mcp4; Synonyms=mug101; ORFNames=SPBC16E9.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17509158; DOI=10.1186/1747-1028-2-14;
RA   Ohtaka A., Saito T.T., Okuzaki D., Nojima H.;
RT   "Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe.";
RL   Cell Div. 2:14-14(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   FUNCTION IN MEIOSIS.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA   Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes required for
RT   critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR   EMBL; AB189988; BAD42850.1; -; Genomic_DNA.
DR   EMBL; CU329671; CAB16900.1; -; Genomic_DNA.
DR   PIR; T39582; T39582.
DR   RefSeq; NP_595790.1; NM_001021691.1.
DR   AlphaFoldDB; O14323; -.
DR   STRING; 4896.SPBC16E9.08.1; -.
DR   PaxDb; O14323; -.
DR   EnsemblFungi; SPBC16E9.08.1; SPBC16E9.08.1:pep; SPBC16E9.08.
DR   GeneID; 2540004; -.
DR   KEGG; spo:SPBC16E9.08; -.
DR   PomBase; SPBC16E9.08; mcp4.
DR   VEuPathDB; FungiDB:SPBC16E9.08; -.
DR   HOGENOM; CLU_781103_0_0_1; -.
DR   PRO; PR:O14323; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR   GO; GO:0005628; C:prospore membrane; IDA:PomBase.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IMP:PomBase.
DR   GO; GO:0140043; P:lipid droplet localization to prospore membrane leading edge; EXP:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Meiosis; Reference proteome.
FT   CHAIN           1..355
FT                   /note="Meiotic coiled-coil protein 4"
FT                   /id="PRO_0000096290"
FT   COILED          298..338
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   355 AA;  41580 MW;  C309771BF29399DC CRC64;
     MEPCEDKCKR GLSLNFFEED GPSLRLNSDS LDFLARDFKV EGMSQDNFDQ KTKLYITEES
     LQKEVNIFLT KIYIRESERE PPQSHNSVFQ LLSKIRNSVP NVSAFRNNLS ILSKELSFFS
     FARHIHNRRL CWAEFIYCIR RGIKAIFKTT VQFLPTRLAK IFEKKASEVL KDNLLQTCNS
     KREGEVCDVK EPAVASSESS DCFNDMQELN NIVDLRDYSN SRFQQNRLLD RNLKGWIQGE
     SEKALKGRRT TKRNDKENYN YPDFSNDNEL LFSLATLIVE NNPKKENIIP KYYLRYLQRL
     SRTEINKEII EIEKLELEVV QFQMSIANLI NTQVEVTNTI EELGLRCRPL PNENE