ID   MCP4_THEMA              Reviewed;         566 AA.
AC   Q9X1E2;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Methyl-accepting chemotaxis protein 4;
GN   Name=mcp4; OrderedLocusNames=TM_1428;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
RN   [2]
RP   METHYLATION AT GLU-310; GLU-317; GLN-499 AND GLU-506, AND DEAMIDATION AT
RP   GLN-499.
RX   PubMed=16707700; DOI=10.1128/jb.00181-06;
RA   Perez E., Zheng H., Stock A.M.;
RT   "Identification of methylation sites in Thermotoga maritima chemotaxis
RT   receptors.";
RL   J. Bacteriol. 188:4093-4100(2006).
CC   -!- FUNCTION: Chemotactic-signal transducers respond to changes in the
CC       concentration of attractants and repellents in the environment,
CC       transduce a signal from the outside to the inside of the cell, and
CC       facilitate sensory adaptation through the variation of the level of
CC       methylation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000305}.
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DR   EMBL; AE000512; AAD36498.1; -; Genomic_DNA.
DR   PIR; A72254; A72254.
DR   RefSeq; NP_229228.1; NC_000853.1.
DR   RefSeq; WP_004081682.1; NZ_CP011107.1.
DR   AlphaFoldDB; Q9X1E2; -.
DR   SMR; Q9X1E2; -.
DR   STRING; 243274.THEMA_07175; -.
DR   PRIDE; Q9X1E2; -.
DR   EnsemblBacteria; AAD36498; AAD36498; TM_1428.
DR   KEGG; tma:TM1428; -.
DR   eggNOG; COG0840; Bacteria.
DR   InParanoid; Q9X1E2; -.
DR   OMA; ITHLGEH; -.
DR   OrthoDB; 429006at2; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0006935; P:chemotaxis; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR004010; Double_Cache_2.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR033480; sCache_2.
DR   Pfam; PF08269; dCache_2; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM01049; Cache_2; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Chemotaxis; Membrane; Methylation; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..566
FT                   /note="Methyl-accepting chemotaxis protein 4"
FT                   /id="PRO_0000250996"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          209..261
FT                   /note="HAMP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT   DOMAIN          280..516
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT   MOD_RES         310
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000269|PubMed:16707700"
FT   MOD_RES         317
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000269|PubMed:16707700"
FT   MOD_RES         499
FT                   /note="Glutamate methyl ester (Gln)"
FT                   /evidence="ECO:0000269|PubMed:16707700"
FT   MOD_RES         506
FT                   /note="Glutamate methyl ester (Glu)"
FT                   /evidence="ECO:0000269|PubMed:16707700"
SQ   SEQUENCE   566 AA;  63041 MW;  BAA6BFB8F8A34ACF CRC64;
     MRSIASKVLV IGVVVVLAFF VTQYVLLNTT VFNSIMERKK EEAKHLVESV YGILERAYEM
     EQKGELTREQ AQELAKSLIG KIRYDDNNYF WINDTHPRMV FHPIKPEMNG QDLSNYKDPN
     GVYLFNEMVK VAKEKGEGFV SYSWPKAGSD KPEPKISYVK LFEPWGWIVG TGIYVDDVKV
     TVGNLIFRNV LTVSVIGIAV IIMIFFYGRV LSRKTKAVLS ALEKISSGDL SVSVDIKSKD
     EFGLIAQKLN ETVGNLRKMV QEIDKSQDEV ERVSEELFAL SQQLRSALEE IARASDTISK
     EVQNASASIE EVTSGSEEVS ANSQNISKLI QEISENADNI ADFARNGQRV LEEAVKKVED
     VSENSRETAD VVSNVTESAR NIEEIVRTIQ SIAEQTNLLA LNAAIEAARA GEAGRGFAVV
     ADEIRKLAEE SQKATEEISQ ILENIREGVE RTNEMSKKNV EITKDARRLV EESYESFNQI
     VTRIEDLAAR IEGIAASAQE LSAASEEMSS ALDAVAKTTT TVADEVEEVS ENITEQEKAA
     KRIADIGTEL KKLSDELKED VERFKI