ID   MCP5A_MACPC             Reviewed;         166 AA.
AC   B9V984;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Macrocypin-5a;
OS   Macrolepiota procera (Parasol mushroom).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Agaricaceae; Macrolepiota.
OX   NCBI_TaxID=56183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-44, AND FUNCTION.
RC   TISSUE=Fruiting body;
RX   PubMed=19678836; DOI=10.1111/j.1742-4658.2009.07138.x;
RA   Sabotic J., Popovic T., Puizdar V., Brzin J.;
RT   "Macrocypins, a family of cysteine protease inhibitors from the
RT   basidiomycete Macrolepiota procera.";
RL   FEBS J. 276:4334-4345(2009).
CC   -!- FUNCTION: Inhibits papain and cysteine cathepsin endopeptidases, and
CC       also inhibits cathepsins B and H, which exhibit both exopeptidase and
CC       endopeptidase activities. {ECO:0000269|PubMed:19678836}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I85 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FJ495250; ACL99734.1; -; Genomic_DNA.
DR   AlphaFoldDB; B9V984; -.
DR   SMR; B9V984; -.
DR   MEROPS; I85.003; -.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Thiol protease inhibitor.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:19678836"
FT   CHAIN           2..166
FT                   /note="Macrocypin-5a"
FT                   /id="PRO_0000397843"
FT   REGION          20..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   166 AA;  18967 MW;  39F7752D3B819F18 CRC64;
     MGFEDGFYTI RHLVEGQPPN IPGGMYASSK DGKDEPVTAE PLGPHSKIRW WIARYPEAGE
     DMYTITEFRV DESIPGQWAR PHNEVGGPVY LYDRIRAEET GYVCEWRIQP AYEDVDGVFN
     IMGNSRIGST DWADLREEGG KPQVYLKPVP VVPNMYIPRW FISKVD