MCP7_SCHPO
ID MCP7_SCHPO Reviewed; 210 AA.
AC Q09739;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Meiotic coiled-coil protein 7;
DE AltName: Full=Meiotically up-regulated gene 32 protein;
GN Name=mcp7; Synonyms=mug32; ORFNames=SPAC13A11.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INTERACTION WITH MEU13.
RX PubMed=15210864; DOI=10.1093/nar/gkh654;
RA Saito T.T., Tougan T., Kasama T., Okuzaki D., Nojima H.;
RT "Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates
RT with Meu13 and is required for meiotic recombination.";
RL Nucleic Acids Res. 32:3325-3339(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for meiotic recombination.
CC {ECO:0000269|PubMed:15210864, ECO:0000269|PubMed:16303567}.
CC -!- SUBUNIT: Interacts with meu13. {ECO:0000269|PubMed:15210864}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the MND1 family. {ECO:0000305}.
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DR EMBL; AB189985; BAD42847.1; -; Genomic_DNA.
DR EMBL; CU329670; CAA90804.1; -; Genomic_DNA.
DR PIR; T37610; T37610.
DR RefSeq; NP_592991.1; NM_001018390.2.
DR AlphaFoldDB; Q09739; -.
DR SMR; Q09739; -.
DR BioGRID; 279005; 6.
DR STRING; 4896.SPAC13A11.03.1; -.
DR PaxDb; Q09739; -.
DR EnsemblFungi; SPAC13A11.03.1; SPAC13A11.03.1:pep; SPAC13A11.03.
DR GeneID; 2542548; -.
DR KEGG; spo:SPAC13A11.03; -.
DR PomBase; SPAC13A11.03; mcp7.
DR VEuPathDB; FungiDB:SPAC13A11.03; -.
DR eggNOG; KOG3433; Eukaryota.
DR HOGENOM; CLU_080628_3_1_1; -.
DR InParanoid; Q09739; -.
DR OMA; VCYWAFP; -.
DR PhylomeDB; Q09739; -.
DR PRO; PR:Q09739; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0120231; C:DNA recombinase auxiliary factor complex; IPI:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0120230; F:recombinase activator activity; IDA:PomBase.
DR GO; GO:0000709; P:meiotic joint molecule formation; IDA:PomBase.
DR GO; GO:0010774; P:meiotic strand invasion involved in reciprocal meiotic recombination; IDA:PomBase.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
DR InterPro; IPR040661; LZ3wCH.
DR InterPro; IPR005647; Mnd1.
DR InterPro; IPR040453; Mnd1_HTH.
DR Pfam; PF18517; LZ3wCH; 1.
DR Pfam; PF03962; Mnd1; 1.
DR PIRSF; PIRSF026991; Mnd1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..210
FT /note="Meiotic coiled-coil protein 7"
FT /id="PRO_0000096293"
FT COILED 77..148
FT /evidence="ECO:0000255"
SQ SEQUENCE 210 AA; 24224 MW; F4A546F070A37665 CRC64;
MPPKGLSLAE KRRRLEAIFH DSKDFFQLKE VEKLGSKKQI VLQTVKDVLQ SLVDDNIVKT
EKIGTSNYYW SFPSDAKRSR ESVLGSLQAQ LDDLKQKSKT LDENISFEKS KRDNEGTEND
ANQYTLELLH AKESELKLLK TQLSNLNHCN PETFELKNEN TKKYMEAANL WTDQIHTLIA
FCRDMGADTN QIREYCSIPE DLDDLQLPIL