MCPA_CAUVC
ID MCPA_CAUVC Reviewed; 657 AA.
AC Q00986;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Chemoreceptor McpA;
DE AltName: Full=Methyl-accepting chemotaxis protein;
GN Name=mcpA; OrderedLocusNames=CC_0430;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=1577276; DOI=10.1101/gad.6.5.825;
RA Alley M.R.K., Maddock J.R., Shapiro L.;
RT "Polar localization of a bacterial chemoreceptor.";
RL Genes Dev. 6:825-836(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- FUNCTION: Chemotactic-signal transducers respond to changes in the
CC concentration of attractants and repellents in the environment,
CC transduce a signal from the outside to the inside of the cell, and
CC facilitate sensory adaptation through the variation of the level of
CC methylation. Attractants increase the level of methylation while
CC repellents decrease the level of methylation.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC Note=Localized at the flagellum-bearing pole of the swarmer cell.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000305}.
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DR EMBL; X66502; CAA47122.1; -; Genomic_DNA.
DR EMBL; AE005673; AAK22417.1; -; Genomic_DNA.
DR PIR; S23064; S23064.
DR RefSeq; NP_419249.1; NC_002696.2.
DR AlphaFoldDB; Q00986; -.
DR SMR; Q00986; -.
DR STRING; 190650.CC_0430; -.
DR PRIDE; Q00986; -.
DR EnsemblBacteria; AAK22417; AAK22417; CC_0430.
DR KEGG; ccr:CC_0430; -.
DR PATRIC; fig|190650.5.peg.435; -.
DR eggNOG; COG0840; Bacteria.
DR HOGENOM; CLU_000445_107_20_5; -.
DR OMA; RGEATHS; -.
DR BioCyc; CAULO:CC0430-MON; -.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00015; MCPsignal; 1.
DR PRINTS; PR00260; CHEMTRNSDUCR.
DR SMART; SM00304; HAMP; 2.
DR SMART; SM00283; MA; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 2.
PE 3: Inferred from homology;
KW Cell membrane; Chemotaxis; Membrane; Methylation; Receptor;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..657
FT /note="Chemoreceptor McpA"
FT /id="PRO_0000110545"
FT TOPO_DOM 1..5
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..188
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..657
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 216..269
FT /note="HAMP 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 297..349
FT /note="HAMP 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00102"
FT DOMAIN 354..583
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
FT REGION 634..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 378
FT /note="Glutamate methyl ester (Gln)"
FT /evidence="ECO:0000250"
FT MOD_RES 385
FT /note="Glutamate methyl ester (Glu)"
FT /evidence="ECO:0000250"
FT MOD_RES 392
FT /note="Glutamate methyl ester (Glu)"
FT /evidence="ECO:0000250"
FT MOD_RES 574
FT /note="Glutamate methyl ester (Gln)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 657 AA; 69346 MW; 2D5CC51CA43D7250 CRC64;
MKRIRLVDLP LIIKIGFAPA FALLMLAVMA GGAILVQKSQ SAALKQVVER DMRQNLEIQR
ISKRISNING ELFVVMTHKA GNIDVDKNDA RMAAVLVETD AVKKDLLALK SKLPAEEQPK
IAELIKSLEE CRSAIDTVSG MISVDFNMAA GFIAPFEEQY VKMTGQLDQV VAAANQRIES
ESAKRQAQAT AAMSVTIIMS LLTLGAVGAL AFLTVMTTRK SINDIAAATD KLSKGDNSID
LEKMTRGDEL GGIVTALKVF RDNQVHLEQL RADQEKSAAL TADERRSKEA AAAAAAQEAS
LVVSNLAEGL EKLASGDLTF RVTADFPGDY RKLKDDFNAA MGSLQETMKV IAASTDGLST
GADEIAHASD DLSRRTEQQA ASLEETAAAL DELTATVRRT AAGARQASDV VSTTRGEATH
SGQVVHQAVS AMGEIEKSSG QISQIIGVID EIAFQTNLLA LNAGVEAARA GEAGRGFAVV
AQEVRALAQR SAEAAKEIKA LISSSTQQVS QGVSLVGQTG EALQRIVTKV GEIDALVTEI
AASAAEQATG LNEVNTAVNQ MDQVTQQNAA MVEQSTAATH SLKGETAELV RLMARFQVGS
GSSSYARPAV ADAGHHAPAR NPVAEQQARL NTFARPGRSS GSAALAQAPA SDGWEEF
