MCPA_PSEAE
ID MCPA_PSEAE Reviewed; 390 AA.
AC Q9I6V2;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Methyl-accepting chemotaxis protein McpA {ECO:0000305};
GN Name=mcpA {ECO:0000303|PubMed:12142407};
GN Synonyms=cttP {ECO:0000312|EMBL:AAG03570.1};
GN OrderedLocusNames=PA0180 {ECO:0000312|EMBL:AAG03570.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [2]
RP FUNCTION IN CHEMOTAXIS, AND DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=12142407; DOI=10.1128/jb.184.16.4374-4383.2002;
RA Ferrandez A., Hawkins A.C., Summerfield D.T., Harwood C.S.;
RT "Cluster II che genes from Pseudomonas aeruginosa are required for an
RT optimal chemotactic response.";
RL J. Bacteriol. 184:4374-4383(2002).
CC -!- FUNCTION: Involved in chemotaxis. Required for an optimal chemotactic
CC response. {ECO:0000269|PubMed:12142407}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mutants have general chemotaxis defects in media
CC that are low in magnesium. {ECO:0000269|PubMed:12142407}.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000305}.
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DR EMBL; AE004091; AAG03570.1; -; Genomic_DNA.
DR PIR; A83622; A83622.
DR RefSeq; NP_248870.1; NC_002516.2.
DR RefSeq; WP_003106690.1; NZ_QZGE01000015.1.
DR AlphaFoldDB; Q9I6V2; -.
DR SMR; Q9I6V2; -.
DR STRING; 287.DR97_3136; -.
DR PaxDb; Q9I6V2; -.
DR PRIDE; Q9I6V2; -.
DR EnsemblBacteria; AAG03570; AAG03570; PA0180.
DR GeneID; 879336; -.
DR KEGG; pae:PA0180; -.
DR PATRIC; fig|208964.12.peg.186; -.
DR PseudoCAP; PA0180; -.
DR HOGENOM; CLU_043262_1_0_6; -.
DR InParanoid; Q9I6V2; -.
DR OMA; HIDQMAQ; -.
DR PhylomeDB; Q9I6V2; -.
DR BioCyc; PAER208964:G1FZ6-181-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR InterPro; IPR004089; MCPsignal_dom.
DR Pfam; PF00015; MCPsignal; 1.
DR PRINTS; PR00260; CHEMTRNSDUCR.
DR SMART; SM00283; MA; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Chemotaxis; Membrane; Methylation;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..390
FT /note="Methyl-accepting chemotaxis protein McpA"
FT /id="PRO_0000454747"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 173..265
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00284"
SQ SEQUENCE 390 AA; 42774 MW; B61BC00049D400AA CRC64;
MRESLGVSLP SRPLLLKLGL LSLPWALCAG LHAVGLGVWL VLALGWFASL AMLVLLLRAP
RQAVANANPQ ADAASPAWSA AQRALADETA QLDGHARQID ELLHSAIRQL SDSFHGLAER
IDTQRGLSHS LIERYDGRGQ VDEGINFQDF VRTTQQTLSL FVEATLETSR TSQQLVERMD
QVRLKITEIL QSTQDMDAIA KQTNLLALNA AIEAARAGES GRGFAVVADE VRALSTRSTE
FSAAIRKHVD VVHHEIQDAE SAISQLADKD MSFALDSKHK IQGMLDDLEA MNRHTLKVIH
ELDRLSLEVG QGVDAAVTAL QFQDMGSQLL GQMRKHHARL GAFALGLGAL EARPRQEWPE
RVAREVEELR RPLPSPVSQN SVNVGEVELF
