ID   MCPB_BOVIN              Reviewed;          74 AA.
AC   P80343;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   07-OCT-2020, entry version 66.
DE   RecName: Full=Monocyte chemotactic protein 1B;
DE            Short=MCP-1B;
DE   Flags: Fragment;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Kidney;
RX   PubMed=7947749; DOI=10.1021/bi00249a029;
RA   Proost P., Wuyts A., Lenaerts J.-P., van Damme J.;
RT   "Purification, sequence analysis, and biological characterization of a
RT   second bovine monocyte chemotactic protein-1 (Bo MCP-1B).";
RL   Biochemistry 33:13406-13412(1994).
CC   -!- FUNCTION: Chemotactic factor that attracts monocytes, but not
CC       neutrophils. Augments monocyte anti-tumor activity. Also induces the
CC       release of gelatinase B. This protein can bind heparin.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC       {ECO:0000305}.
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DR   PIR; A55984; A55984.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IBA:GO_Central.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0048245; P:eosinophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR039809; Chemokine_b/g/d.
DR   InterPro; IPR000827; Chemokine_CC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR12015; PTHR12015; 1.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE   1: Evidence at protein level;
KW   Chemotaxis; Cytokine; Direct protein sequencing; Disulfide bond;
KW   Heparin-binding; Reference proteome.
FT   CHAIN           <1..74
FT                   /note="Monocyte chemotactic protein 1B"
FT                   /id="PRO_0000144304"
FT   DISULFID        9..34
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..50
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   74 AA;  8363 MW;  FAAF72B970EB16E3 CRC64;
     DAINSPVTCC YTLTSKKISM QRLMSYRRVT SSKCPKEAVI FKTIAGKEIC AEPKXXWVQD
     SISHLDKKNQ XPKP