ID   MCPT3_MOUSE             Reviewed;          21 AA.
AC   P21843;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Mast cell protease 3;
DE            Short=mMCP-3;
DE            EC=3.4.21.-;
DE   Flags: Fragment;
GN   Name=Mcpt3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2326280; DOI=10.1073/pnas.87.8.3230;
RA   Reynolds D.S., Stevens R.L., Lane W.S., Carr M.H., Austen K.F.,
RA   Serafin W.E.;
RT   "Different mouse mast cell populations express various combinations of at
RT   least six distinct mast cell serine proteases.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:3230-3234(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-16.
RC   TISSUE=Peritoneal exudate;
RX   PubMed=8505310; DOI=10.1016/s0021-9258(19)50273-3;
RA   Pejler G., Karlstroem A.;
RT   "Thrombin is inactivated by mast cell secretory granule chymase.";
RL   J. Biol. Chem. 268:11817-11822(1993).
CC   -!- FUNCTION: Thrombin inactivating protease. Displays chymotrypsin-like
CC       substrate specificity.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Granzyme subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
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DR   PIR; A35646; A35646.
DR   AlphaFoldDB; P21843; -.
DR   MEROPS; S01.140; -.
DR   PRIDE; P21843; -.
DR   ProteomicsDB; 295843; -.
DR   MGI; MGI:96939; Mcpt3.
DR   Proteomes; UP000000589; Unplaced.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Protease; Reference proteome;
KW   Serine protease.
FT   CHAIN           1..>21
FT                   /note="Mast cell protease 3"
FT                   /id="PRO_0000088658"
FT   DOMAIN          1..>21
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         21
SQ   SEQUENCE   21 AA;  2328 MW;  6C840866E9D6FA01 CRC64;
     IIGGVESRPH SRPYMATLEI T