ID   MCP_FRG3G               Reviewed;         463 AA.
AC   Q67473; Q6GZN5;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 81.
DE   RecName: Full=Major capsid protein;
DE            Short=MCP;
DE   AltName: Full=P50;
GN   ORFNames=FV3-090R;
OS   Frog virus 3 (isolate Goorha) (FV-3).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus.
OX   NCBI_TaxID=654924;
OH   NCBI_TaxID=30343; Dryophytes versicolor (chameleon treefrog).
OH   NCBI_TaxID=8404; Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OH   NCBI_TaxID=45438; Lithobates sylvaticus (Wood frog) (Rana sylvatica).
OH   NCBI_TaxID=8316; Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8607274; DOI=10.1006/viro.1996.0080;
RA   Mao J., Tham T.N., Gentry G.A., Aubertin A., Chinchar V.G.;
RT   "Cloning, sequence analysis, and expression of the major capsid protein of
RT   the iridovirus frog virus 3.";
RL   Virology 216:431-436(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15165820; DOI=10.1016/j.virol.2004.02.019;
RA   Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.;
RT   "Comparative genomic analyses of frog virus 3, type species of the genus
RT   Ranavirus (family Iridoviridae).";
RL   Virology 323:70-84(2004).
RN   [3]
RP   FUNCTION.
RX   PubMed=2418581; DOI=10.1016/0042-6822(86)90085-1;
RA   Darcy-Tripier F., Nermut M.V., Brown E., Nonnenmacher H., Braunwald J.;
RT   "Ultrastructural and biochemical evidence of the trimeric nature of frog
RT   virus 3 (FV3) six-coordinated capsomers.";
RL   Virology 149:44-54(1986).
CC   -!- FUNCTION: Major capsid protein that self assembles to form a T=133 or
CC       T=147 icosahedral capsid. {ECO:0000269|PubMed:2418581}.
CC   -!- SUBUNIT: Homomultimer.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NCLDV major capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; U36913; AAB01722.1; -; Genomic_DNA.
DR   EMBL; AY548484; AAT09750.1; -; Genomic_DNA.
DR   RefSeq; YP_031669.1; NC_005946.1.
DR   SMR; Q67473; -.
DR   GeneID; 2947809; -.
DR   KEGG; vg:2947809; -.
DR   Proteomes; UP000008770; Genome.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 2.70.9.20; -; 1.
DR   InterPro; IPR031654; Capsid_N.
DR   InterPro; IPR007542; MCP_C.
DR   InterPro; IPR038519; MCP_C_sf.
DR   InterPro; IPR016112; VP_dsDNA_II.
DR   Pfam; PF16903; Capsid_N; 1.
DR   Pfam; PF04451; Capsid_NCLDV; 1.
DR   SUPFAM; SSF49749; SSF49749; 2.
PE   3: Inferred from homology;
KW   Capsid protein; Late protein; Reference proteome; Virion.
FT   CHAIN           1..463
FT                   /note="Major capsid protein"
FT                   /id="PRO_0000222379"
SQ   SEQUENCE   463 AA;  49917 MW;  E20D6EFF1A48AD2A CRC64;
     MSSVTGSGIT SGFIDLATYD NLERAMYGGS DATTYFVKEH YPVGWFTKLP SLAAKMSGNP
     AFGQQFSVGV PRSGDYILNA WLVLKTPEVE LLAANQLGDN GTIRWTKNPM HNIVESVTLS
     FNDISAQSFN TAYLDAWSEY TMPEAKRTGY YNMIGNTSDL INPAPATGQD GARVLPAKNL
     VLPLPFFFSR DSGLALPVVS LPYNEIRITV KLRAIHDLLI LQHNTTGAIS PIVASDLAGG
     LPDTVEANVY MTVALITGDE RQAMSSTVRD MVVEQVQAAP VHMVNPRNAT TFHTDMRFSH
     AVKALMFMVQ NVTHPSVGSN YTCVTPVVGV GNTVLEPALA VDPVKSASLV YENTTRLPDM
     GVEYYSLVEP WYYATSIPVS TGHHLYSYAL SLQDPHPSGS TNYGRLTNAS LNVTLSAEAT
     TAAAGGGGNN SGYTTAQKYA LIVLAINHNI IRIMNGSMGF PIL