ID   MCP_HHV6U               Reviewed;        1345 AA.
AC   P17887;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 3.
DT   02-DEC-2020, entry version 83.
DE   RecName: Full=Major capsid protein {ECO:0000255|HAMAP-Rule:MF_04016};
DE            Short=MCP {ECO:0000255|HAMAP-Rule:MF_04016};
GN   Name=MCP {ECO:0000255|HAMAP-Rule:MF_04016}; Synonyms=4L, U57;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2153237; DOI=10.1128/jvi.64.2.714-722.1990;
RA   Littler E., Lawrence G., Liu M.-Y., Barrell B.G., Arrand J.R.;
RT   "Identification, cloning, and expression of the major capsid protein gene
RT   of human herpesvirus 6.";
RL   J. Virol. 64:714-722(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2152817; DOI=10.1128/jvi.64.1.287-299.1990;
RA   Lawrence G.L., Chee M., Craxton M.A., Gompels U.A., Honess R.W.,
RA   Barrell B.G.;
RT   "Human herpesvirus 6 is closely related to human cytomegalovirus.";
RL   J. Virol. 64:287-299(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Self-assembles to form an icosahedral capsid with a T=16
CC       symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12
CC       pentons (total of 162 capsomers). Hexons form the edges and faces of
CC       the capsid and are each composed of six MCP molecules. In contrast, one
CC       penton is found at each of the 12 vertices. Eleven of the pentons are
CC       MCP pentamers, while the last vertex is occupied by the portal complex.
CC       The capsid is surrounded by a layer of proteinaceous material
CC       designated the tegument which, in turn, is enclosed in an envelope of
CC       host cell-derived lipids containing virus-encoded glycoproteins.
CC       {ECO:0000255|HAMAP-Rule:MF_04016}.
CC   -!- SUBUNIT: Homomultimer. Makes the hexons and eleven out of twelve
CC       pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent
CC       capsomers are linked together in groups of three by triplexes,
CC       heterotrimeric complexes composed of one molecule of TRX1 and two
CC       molecules of TRX2. Interacts with scaffold protein; this interaction
CC       allows efficient MCP transport to the host nucleus. Interacts with
CC       capsid vertex component 2/CVC2. Interacts with the small capsomere-
CC       interacting protein/SCP. {ECO:0000255|HAMAP-Rule:MF_04016}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04016}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04016}.
CC   -!- SIMILARITY: Belongs to the herpesviridae major capsid protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04016}.
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DR   EMBL; M33515; AAA51531.1; -; Genomic_DNA.
DR   EMBL; M68963; AAA65567.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58391.1; -; Genomic_DNA.
DR   PIR; E33560; VCBEH6.
DR   RefSeq; NP_042950.1; NC_001664.2.
DR   SMR; P17887; -.
DR   PRIDE; P17887; -.
DR   GeneID; 1487939; -.
DR   KEGG; vg:1487939; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039622; C:T=16 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04016; HSV_MCP; 1.
DR   InterPro; IPR000912; Herpes_MCP.
DR   InterPro; IPR023233; Herpes_MCP_upper_sf.
DR   Pfam; PF03122; Herpes_MCP; 1.
DR   PRINTS; PR00235; HSVCAPSIDMCP.
DR   SUPFAM; SSF103417; SSF103417; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host nucleus; Reference proteome;
KW   T=16 icosahedral capsid protein; Virion.
FT   CHAIN           1..1345
FT                   /note="Major capsid protein"
FT                   /id="PRO_0000115705"
FT   CONFLICT        344
FT                   /note="E -> K (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        779
FT                   /note="K -> E (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1345 AA;  151951 MW;  F1DE8D083A85A949 CRC64;
     MENWQATEIL PKIEAPLNIF NDIKTYTAEQ LFDNLRIYFG DDPSRYNISF EALLGIYCNK
     IEWINFFTTP IAVAANVIRF NDVSRMTLGK VLFFIQLPRV ATGNDVTASK ETTIMVAKHS
     EKHPINISFD LSAACLEHLE NTFKNTVIDQ ILNINALHTV LRSLKNSADS LERGLIHAFM
     QTLLRKSPPQ FIVLTMNENK VHNKQALSRV QRSNMFQSLK NRLLTSLFFL NRNNNISYIY
     RILNDMMESV TESILNDTNN YTSKENVPLD GVLLGPIGSI QKLTSILSQY ISTQVVSAPI
     SYGHFIMGKE NAVTAIAYRA IMADFTQFTV NAGTEQQDTN NKSEIFDKSR AYADLKLNTL
     KLGDKLVAFD HLHKVYKNTD VNDPLEQSLQ LTFFFPLGIY IPSETGFSTM ETRVKLNDTM
     ENNLPTSVFF HNKDQVVQRI DFADILPSVC HPIVHDSTIV ERLMKSEPLP TGHRFSQLCQ
     LKITRENPAR ILQTLYNLYE SRQEVPKNTN VLKNELNIED FYKPDNPTLP TERHPFFDLT
     YIQKNRATEV LCTPRIMIGN IPLPLAPVSF HEARTNQILE HAKTNCQKYD FTLKIVTESL
     TSGSYPELAY VIETLVHGNK HAFMILKQVI SQCISYWFNM KHILLFCNSF EMIMLISNHM
     GDELIPGAAF AHYRNLVSLI RLVKRTISIS NLNEQLCGEP LVNFANALFD GRLFCPFVHT
     MPRNDTNAKI TADDTPLTQN TVRVRNYEIS DVQRMNLIDS SVVFTDNDRP SNETTILSKI
     FYFCVLPALS NNKACGAGVN VKELVLDLFY TEPFISPDDY FQENPITSDV LMSLIREGMG
     PGYTVANTSC IAKQLFKSLI YINENTKILE VEVSLDPAQR HGNSVHFQSL QHILYNGLCL
     ISPITTLRRY YQPIPFHRFF SDPGICGTMN ADIQVFLNTF PHCQRNDGGF PLPPPLALEF
     YNWQRTPFSV YSAFCPNSLL SIMTLAAMHS KLSPVAIAIQ SKNKIHPGFA ATLVRTDNFD
     VECLLYSSRA ATSIILDDPT VTAEAKDIAT TYNFTQHLSF VDMGLGFSST TATANLKRIK
     SDMGSKIQNL FSAFPIHAFT NADINTWIRH HVGIEKPNPS ESEALNIITF GGINKNPPSI
     LLHGQQAICE VILTPVTTNI NFFKSPHNPR GRESCMMGTD PHNEEAARKA LYDHTQTDSD
     TFAATTNPWA SLPGSLGDIL YNTAHREQLC YNPKTYSPNA QFFTESDILK TNKMMYKVIS
     EYCMKSNSCL NSDSEIQYSC SEGTDSFVSR PCQFLQNALP LHCSSNQALL ESRSKTGNTQ
     ISETHYCNYA IGETIPFQLI IESSI