ID   MCP_IRV22               Reviewed;         472 AA.
AC   P22166;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   23-FEB-2022, entry version 72.
DE   RecName: Full=Major capsid protein;
DE            Short=MCP;
DE   AltName: Full=P50;
GN   Name=MCP;
OS   Simulium iridescent virus (IIV-22) (Insect iridescent virus type 22).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Betairidovirinae; Chloriridovirus.
OX   NCBI_TaxID=10489;
OH   NCBI_TaxID=7191; Simulium.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=2389558; DOI=10.1016/0042-6822(90)90376-3;
RA   Cameron I.R.;
RT   "Identification and characterization of the gene encoding the major
RT   structural protein of insect iridescent virus type 22.";
RL   Virology 178:35-42(1990).
CC   -!- FUNCTION: Major capsid protein that self assembles to form an
CC       icosahedral capsid. Represents around 50% of the total virion protein
CC       mass (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the NCLDV major capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; M32799; AAA66585.1; -; Genomic_DNA.
DR   PIR; B37075; VCXFSI.
DR   SMR; P22166; -.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 2.70.9.20; -; 1.
DR   InterPro; IPR031654; Capsid_N.
DR   InterPro; IPR007542; MCP_C.
DR   InterPro; IPR038519; MCP_C_sf.
DR   InterPro; IPR016112; VP_dsDNA_II.
DR   Pfam; PF16903; Capsid_N; 1.
DR   Pfam; PF04451; Capsid_NCLDV; 1.
DR   SUPFAM; SSF49749; SSF49749; 2.
PE   1: Evidence at protein level;
KW   Capsid protein; Direct protein sequencing; Late protein; Virion.
FT   CHAIN           1..472
FT                   /note="Major capsid protein"
FT                   /id="PRO_0000222384"
SQ   SEQUENCE   472 AA;  51993 MW;  B3D81F790AE9EFE9 CRC64;
     MSMSSSNITS GFIDIATFDE IEKYMYGGPT ATAYFVREIR KSTWFTQVPV PLSRNTGNAA
     FGQEWSVSIS RAGDYLLQTW LRVNIPPVTL SGLLGNTYSL RWTKNLMHNL IREATITFND
     LVAARFDNYH LDFWSAFTVP ASKRNGYDNM IGNVSSLINP VAPGGTLGSV GGINLNLPLP
     FFFSRDTGVA LPTAALPYNE MQINFNFRDW HELLILTNSA LVPPASSYVS IVVGTHISAA
     PVLGPVQVWA NYAIVSNEER RRMGCAIRDI LIEQVQTAPR QNYVPLTNAS PTFDIRFSHA
     IKALFFAVRN KTSAAEWSNY ATSSPVVTGA TVNYEPTGSF DPIANTTLIY ENTNRLGAMG
     SDYFSLINPF YHAPTIPSFI GYHLYSYSLH FYDLDPMGST NYGKLTNVFV VPAASSAAIS
     AAGGTGGQAG SDYAQSYEFV IVAVNNNIVR IENSLVRNRR RWSREGPMVM VC