ID   MCP_LCDV1               Reviewed;         459 AA.
AC   P22176;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   23-FEB-2022, entry version 91.
DE   RecName: Full=Major capsid protein;
DE            Short=MCP;
DE   AltName: Full=P50;
GN   Name=MCP;
OS   Lymphocystis disease virus 1 (isolate Darai) (LCDV-1).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Alphairidovirinae; Lymphocystivirus.
OX   NCBI_TaxID=654922;
OH   NCBI_TaxID=30942; Pleuronectoidei.
RN   [1]
RP   PRELIMINARY NUCLEOTIDE SEQUENCE.
RC   STRAIN=F;
RX   PubMed=2024501; DOI=10.1016/0042-6822(91)90625-l;
RA   Schnitzler P., Handermann M., Szepe O., Darai G.;
RT   "The primary structure of the thymidine kinase gene of fish lymphocystis
RT   disease virus.";
RL   Virology 182:835-840(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9143276; DOI=10.1006/viro.1997.8456;
RA   Tidona C.A., Darai G.;
RT   "The complete DNA sequence of lymphocystis disease virus.";
RL   Virology 230:207-216(1997).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=8409939; DOI=10.1099/0022-1317-74-10-2143;
RA   Schnitzler P., Darai G.;
RT   "Identification of the gene encoding the major capsid protein of fish
RT   lymphocystis disease virus.";
RL   J. Gen. Virol. 74:2143-2150(1993).
CC   -!- FUNCTION: Major capsid protein that self assembles to form an
CC       icosahedral capsid. Represents around 50% of the total virion protein
CC       mass (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NCLDV major capsid protein family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Was originally thought to be a thymidine kinase.
CC       {ECO:0000305|PubMed:2024501}.
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DR   EMBL; L63545; AAC24486.2; -; Genomic_DNA.
DR   PIR; JQ2345; KIXFFV.
DR   RefSeq; NP_044812.1; NC_001824.1.
DR   SMR; P22176; -.
DR   GeneID; 1497288; -.
DR   KEGG; vg:1497288; -.
DR   Proteomes; UP000000516; Genome.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   Gene3D; 2.70.9.20; -; 1.
DR   InterPro; IPR031654; Capsid_N.
DR   InterPro; IPR007542; MCP_C.
DR   InterPro; IPR038519; MCP_C_sf.
DR   InterPro; IPR016112; VP_dsDNA_II.
DR   Pfam; PF16903; Capsid_N; 1.
DR   Pfam; PF04451; Capsid_NCLDV; 1.
DR   SUPFAM; SSF49749; SSF49749; 2.
PE   3: Inferred from homology;
KW   Capsid protein; Late protein; Reference proteome; Virion.
FT   CHAIN           1..459
FT                   /note="Major capsid protein"
FT                   /id="PRO_0000222378"
SQ   SEQUENCE   459 AA;  51347 MW;  4EF4C173B4C35D9B CRC64;
     MTSVAGSSVT SAFIDLATYD TIEKHLYGGD SAVAYFVRET KKCTWFSKLP VLLTRCSGSP
     NFDQEFSVNV SRGGDYVLNS WMTVRIPAIK LKADNRMNNN GTIRWCKNLF HNLIKQTSVQ
     FNDLVAQKFE SYFLDYWAAF SMCGSKRAGY NNMIGNTIDM IQPVDHTGML PEKVLVLPLP
     YFFSRDSGVA LPSAALPYNE IRLTFHLRDY TELLIFQHKQ DCTIIPITAA DLEYGKPDLK
     DVQVWITNAV VTNEERRLMG TTPRDILVEQ VQTAPKHVFQ PLTIPSPNFD IRFSHAIKLL
     FFGVRNTTHA AVQSNYTTAS PVILEEAYAS DLSLVAADPI ANVTLVYENS ARLNEMGSEY
     YSLVQPYYFG GSIPIETGYH MYCYSLNMMD MDPMGSTNYG RLSNVSMKLK TSDKAVVNAG
     GGGGNMSGYK DAQKFEFLTM AINHNVIRIK NGSMGFPVL