ID   MCP_NPVAC               Reviewed;         347 AA.
AC   P17499;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Major capsid protein;
GN   Name=P39; Synonyms=VP39; ORFNames=ORF89;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=L1;
RX   PubMed=2649691; DOI=10.1128/jvi.63.5.2008-2018.1989;
RA   Thiem S.M., Miller L.K.;
RT   "Identification, sequence, and transcriptional mapping of the major capsid
RT   protein gene of the baculovirus Autographa californica nuclear polyhedrosis
RT   virus.";
RL   J. Virol. 63:2008-2018(1989).
RN   [2]
RP   SEQUENCE REVISION.
RA   Miller L.K.;
RL   Submitted (MAR-1989) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [4]
RP   INTERACTION WITH HOST ACTIN.
RX   PubMed=9527926; DOI=10.1006/viro.1998.9065;
RA   Lanier L.M., Volkman L.E.;
RT   "Actin binding and nucleation by Autographa california M
RT   nucleopolyhedrovirus.";
RL   Virology 243:167-177(1998).
RN   [5]
RP   INTERACTION WITH PROTEIN 38K.
RX   PubMed=18922869; DOI=10.1128/jvi.00948-08;
RA   Wu W., Liang H., Kan J., Liu C., Yuan M., Liang C., Yang K., Pang Y.;
RT   "Autographa californica multiple nucleopolyhedrovirus 38K is a novel
RT   nucleocapsid protein that interacts with VP1054, VP39, VP80, and itself.";
RL   J. Virol. 82:12356-12364(2008).
RN   [6]
RP   SUBCELLULAR LOCATION.
RX   PubMed=25142609; DOI=10.1128/jvi.01313-14;
RA   Yang M., Wang S., Yue X.L., Li L.L.;
RT   "Autographa californica multiple nucleopolyhedrovirus orf132 encodes a
RT   nucleocapsid-associated protein required for budded-virus and multiply
RT   enveloped occlusion-derived virus production.";
RL   J. Virol. 88:12586-12598(2014).
CC   -!- FUNCTION: Most abundant structural protein of the nucleocapsid produced
CC       during the infection cycle. The monomers are arranged in stacked rings
CC       around the nucleoprotein core.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:25142609}.
CC   -!- MISCELLANEOUS: Expressed late in infection.
CC   -!- SIMILARITY: Belongs to the baculoviridae major capsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; M22978; AAA02580.1; -; Unassigned_DNA.
DR   EMBL; L22858; AAA66719.1; -; Genomic_DNA.
DR   PIR; A31476; VCNVL1.
DR   RefSeq; NP_054119.1; NC_001623.1.
DR   PRIDE; P17499; -.
DR   GeneID; 1403922; -.
DR   KEGG; vg:1403922; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0044204; C:host cell nuclear matrix; IDA:UniProtKB.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0044423; C:virion component; IDA:UniProtKB.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR007589; Baculo_VP39.
DR   Pfam; PF04501; Baculo_VP39; 1.
PE   1: Evidence at protein level;
KW   Capsid protein; Late protein; Reference proteome; Virion.
FT   CHAIN           1..347
FT                   /note="Major capsid protein"
FT                   /id="PRO_0000132900"
SQ   SEQUENCE   347 AA;  38951 MW;  BC939522DEFEC369 CRC64;
     MALVPVGMAP RQMRVNRCIF ASIVSFDACI TYKSPCSPDA YHDDGWFICN NHLIKRFKMS
     KMVLPIFDED DNQFKMTIAR HLVGNKERGI KRILIPSATN YQDVFNLNSM MQAEQLIFHL
     IYNNENAVNT ICDNLKYTEG FTSNTQRVIH SVYATTKSIL DTTNPNTFCS RVSRDELRFF
     DVTNARALRG GAGDQLFNNY SGFLQNLIRR AVAPEYLQID TEELRFRNCA TCIIDETGLV
     ASVPDGPELY NPIRSSDIMR SQPNRLQIRN VLKFEGDTRE LDRTLSGYEE YPTYVPLFLG
     YQIINSENNF LRNDFIPRAN PNATLGGGAV AGPAPGVAGE AGGGIAV