MCP_SUHVS
ID MCP_SUHVS Reviewed; 1330 AA.
AC Q00705;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 23-FEB-2022, entry version 60.
DE RecName: Full=Major capsid protein {ECO:0000255|HAMAP-Rule:MF_04016};
DE Short=MCP {ECO:0000255|HAMAP-Rule:MF_04016};
GN Name=MCP {ECO:0000255|HAMAP-Rule:MF_04016};
OS Suid herpesvirus 1 (strain Indiana S) (SuHV-1) (Pseudorabies virus (strain
OS Indiana S)).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=31522;
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1718089; DOI=10.1016/0042-6822(91)90753-x;
RA Yamada S., Imada T., Watanabe W., Honda Y., Nakajima-Iijima S., Shimizu Y.,
RA Sekikawa K.;
RT "Nucleotide sequence and transcriptional mapping of the major capsid
RT protein gene of pseudorabies virus.";
RL Virology 185:56-66(1991).
CC -!- FUNCTION: Self-assembles to form an icosahedral capsid with a T=16
CC symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12
CC pentons (total of 162 capsomers). Hexons form the edges and faces of
CC the capsid and are each composed of six MCP molecules. In contrast, one
CC penton is found at each of the 12 vertices. Eleven of the pentons are
CC MCP pentamers, while the last vertex is occupied by the portal complex.
CC The capsid is surrounded by a layer of proteinaceous material
CC designated the tegument which, in turn, is enclosed in an envelope of
CC host cell-derived lipids containing virus-encoded glycoproteins.
CC {ECO:0000255|HAMAP-Rule:MF_04016}.
CC -!- SUBUNIT: Homomultimer. Makes the hexons and eleven out of twelve
CC pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent
CC capsomers are linked together in groups of three by triplexes,
CC heterotrimeric complexes composed of one molecule of TRX1 and two
CC molecules of TRX2. Interacts with scaffold protein; this interaction
CC allows efficient MCP transport to the host nucleus. Interacts with
CC capsid vertex component 2/CVC2. Interacts with the small capsomere-
CC interacting protein/SCP. {ECO:0000255|HAMAP-Rule:MF_04016}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04016}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04016}.
CC -!- SIMILARITY: Belongs to the herpesviridae major capsid protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04016}.
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DR PIR; A40777; VCBES5.
DR SMR; Q00705; -.
DR DIP; DIP-62100N; -.
DR PRIDE; Q00705; -.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039622; C:T=16 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04016; HSV_MCP; 1.
DR InterPro; IPR000912; Herpes_MCP.
DR InterPro; IPR023233; Herpes_MCP_upper_sf.
DR Pfam; PF03122; Herpes_MCP; 1.
DR PRINTS; PR00235; HSVCAPSIDMCP.
DR SUPFAM; SSF103417; SSF103417; 1.
PE 3: Inferred from homology;
KW Capsid protein; Host nucleus; T=16 icosahedral capsid protein; Virion.
FT CHAIN 1..1330
FT /note="Major capsid protein"
FT /id="PRO_0000115708"
SQ SEQUENCE 1330 AA; 145938 MW; 4E228145F773A522 CRC64;
MERPAILPSG QILSNIEVHS HRALFDIFKR FRSDDNNLYG AEFDALLGTY CSTLSLVRFL
ELGLSVACVC TKFPELSYVA EGTIQFEVQQ PMIARDGPHP ADQPVHNYMI KRLDRRSLNA
AFSIAVEALG LISGENLDGT HISSAMRLRA IQQLARNVQA VLDSFERGTA DQMLRVLMEK
APPLSLLAPF TLYEGRLADR VACAALVSEL KRRVRDDTFF LTKHERNKDA VLDRLSDLVN
CTAPSVAVAR MTHADTQGRP VDGVLVTTAG VRQRLLHHVL TLADTHADVP VTYGEMVIAN
TNLVTALVMG KAVSNMDDVA RYLLGGEPAP DDGKPVGSAR VRADLVVVGD RLVFLEALEK
RVYQATQVPY PLVGNLDVTF VMPLGVFKPA ADRYARHAGS FAPTPGLPDP RTHPPRAVHF
FNKDGVPCHV TFEHAMGTLC HPSFLDVDAT LAALRQEPAE VQCAFGAYVA DARPDALVGL
MQRFLEEWPG MMPVRPRWAA PAAADQLLAP GNADLRLELH PAFDFFVAPE VDVPGPFAVP
QVMGQVRAMP RIINGNIPLA LCPVDFRDAR GFELSVDRHR LAPATVAAVR GAFRDANYPM
VFYIIEAVIH GSERTFCALA RLVAQCIQSY WRNTHNAAFV NNFYMVMYIN TYLGNGELPE
DCAAVYKDLL EHVHALRRLI GEFTLPGDPL GNQPQEELNH ALADATLLPP LIWDCDPILY
RDGLAERLPE LRVNGAHFQH ILWVEMAQVN FRNVGGGLVH NRPVRNENQP LHPHHDAEWS
VLSKIYYYAV VPAFSRGNCC TMGVRYDRVY QLVQTMVVPE TDEEVGTDDP RHPLHPRNLV
PNSLNVLFHN ACVAVDADAM LILQETVTNM AERTTPLLAS VAPDAGMATV ATRDMRTHDG
SLHHGLLMMA YQPNDATLLE GAFFYPAPVN ALFACADHLG AMRDVGAEVR AAAQHVPCVP
HFLGANYYAT VRQPVAQHAA QSRADENTLS YALMAGYFKM SPVAFTHQLR RQLHPGFALT
VVRQDRFATE NVLFAEKASE SYFMGQMQVA RTESGGGLHL QLTQPRANVD LGVGFTAAYA
AAALRAPVTD MGNLPQNLFA TRGAPPMLDA DADDYLRRTV NAGNRLAPVP VFGQMLPQVP
AGLARGQQSV CEFIATPVSV DLAYFRRACN PRGRAAGEVH GEEGLMFDHS HADPAHPHRA
TANPWASQRH SYADRLYNGQ YNMSGPAYSP CFKFFTPAEA VAKSRGLARL IADTGAAASP
TSNGEYQFKR PVGAGELVED PCALFQEAYP PLCASDSALL RTPLGAEEHF AQYLIRDESP
LKGCFQHASA