MCP_VZVD
ID MCP_VZVD Reviewed; 1396 AA.
AC P09245;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 02-DEC-2020, entry version 72.
DE RecName: Full=Major capsid protein {ECO:0000255|HAMAP-Rule:MF_04016};
DE Short=MCP {ECO:0000255|HAMAP-Rule:MF_04016};
GN Name=MCP {ECO:0000255|HAMAP-Rule:MF_04016}; Synonyms=40;
OS Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=10338;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA Davison A.J., Scott J.E.;
RT "The complete DNA sequence of varicella-zoster virus.";
RL J. Gen. Virol. 67:1759-1816(1986).
CC -!- FUNCTION: Self-assembles to form an icosahedral capsid with a T=16
CC symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12
CC pentons (total of 162 capsomers). Hexons form the edges and faces of
CC the capsid and are each composed of six MCP molecules. In contrast, one
CC penton is found at each of the 12 vertices. Eleven of the pentons are
CC MCP pentamers, while the last vertex is occupied by the portal complex.
CC The capsid is surrounded by a layer of proteinaceous material
CC designated the tegument which, in turn, is enclosed in an envelope of
CC host cell-derived lipids containing virus-encoded glycoproteins.
CC {ECO:0000255|HAMAP-Rule:MF_04016}.
CC -!- SUBUNIT: Homomultimer. Makes the hexons and eleven out of twelve
CC pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent
CC capsomers are linked together in groups of three by triplexes,
CC heterotrimeric complexes composed of one molecule of TRX1 and two
CC molecules of TRX2. Interacts with scaffold protein; this interaction
CC allows efficient MCP transport to the host nucleus. Interacts with
CC capsid vertex component 2/CVC2. Interacts with the small capsomere-
CC interacting protein/SCP. {ECO:0000255|HAMAP-Rule:MF_04016}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04016}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04016}.
CC -!- SIMILARITY: Belongs to the herpesviridae major capsid protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04016}.
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DR EMBL; X04370; CAA27923.1; -; Genomic_DNA.
DR PIR; E27341; VCBE40.
DR SMR; P09245; -.
DR PRIDE; P09245; -.
DR Proteomes; UP000002602; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039622; C:T=16 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_04016; HSV_MCP; 1.
DR InterPro; IPR000912; Herpes_MCP.
DR InterPro; IPR023233; Herpes_MCP_upper_sf.
DR Pfam; PF03122; Herpes_MCP; 1.
DR PRINTS; PR00235; HSVCAPSIDMCP.
DR SUPFAM; SSF103417; SSF103417; 1.
PE 3: Inferred from homology;
KW Capsid protein; Host nucleus; Reference proteome;
KW T=16 icosahedral capsid protein; Virion.
FT CHAIN 1..1396
FT /note="Major capsid protein"
FT /id="PRO_0000115707"
SQ SEQUENCE 1396 AA; 154980 MW; E509272D8D77242F CRC64;
MTTVSCPANV ITTTESDRIA GLFNIPAGII PTGNVLSTIE VCAHRCIFDF FKQIRSDDNS
LYSAQFDILL GTYCNTLNFV RFLELGLSVA CICTKFPELA YVRDGVIQFE VQQPMIARDG
PHPVDQPVHN YMVKRIHKRS LSAAFAIASE ALSLLSNTYV DGTEIDSSLR IRAIQQMARN
LRTVLDSFER GTADQLLGVL LEKAPPLSLL SPINKFQPEG HLNRVARAAL LSDLKRRVCA
DMFFMTRHAR EPRLISAYLS DMVSCTQPSV MVSRITHTNT RGRQVDGVLV TTATLKRQLL
QGILQIDDTA ADVPVTYGEM VLQGTNLVTA LVMGKAVRGM DDVARHLLDI TDPNTLNIPS
IPPQSNSDST TAGLPVNARV PADLVIVGDK LVFLEALERR VYQATRVAYP LIGNIDITFI
MPMGVFQANS MDRYTRHAGD FSTVSEQDPR QFPPQGIFFY NKDGILTQLT LRDAMGTICH
SSLLDVEATL VALRQQHLDR QCYFGVYVAE GTEDTLDVQM GRFMETWADM MPHHPHWVNE
HLTILQFIAP SNPRLRFELN PAFDFFVAPG DVDLPGPQRP PEAMPTVNAT LRIINGNIPV
PLCPISFRDC RGTQLGLGRH TMTPATIKAV KDTFEDRAYP TIFYMLEAVI HGNERNFCAL
LRLLTQCIRG YWEQSHRVAF VNNFHMLMYI TTYLGNGELP EVCINIYRDL LQHVRALRQT
ITDFTIQGEG HNGETSEALN NILTDDTFIA PILWDCDALI YRDEAARDRL PAIRVSGRNG
YQALHFVDMA GHNFQRRDNV LIHGRPVRGD TGQGIPITPH HDREWGILSK IYYYIVIPAF
SRGSCCTMGV RYDRLYPALQ AVIVPEIPAD EEAPTTPEDP RHPLHAHQLV PNSLNVYFHN
AHLTVDGDAL LTLQELMGDM AERTTAILVS SAPDAGAATA TTRNMRIYDG ALYHGLIMMA
YQAYDETIAT GTFFYPVPVN PLFACPEHLA SLRGMTNARR VLAKMVPPIP PFLGANHHAT
IRQPVAYHVT HSKSDFNTLT YSLLGGYFKF TPISLTHQLR TGFHPGIAFT VVRQDRFATE
QLLYAERASE SYFVGQIQVH HHDAIGGVNF TLTQPRAHVD LGVGYTAVCA TAALRCPLTD
MGNTAQNLFF SRGGVPMLHD NVTESLRRIT ASGGRLNPTE PLPIFGGLRP ATSAGIARGQ
ASVCEFVAMP VSTDLQYFRT ACNPRGRASG MLYMGDRDAD IEAIMFDHTQ SDVAYTDRAT
LNPWASQKHS YGDRLYNGTY NLTGASPIYS PCFKFFTPAE VNTNCNTLDR LLMEAKAVAS
QSSTDTEYQF KRPPGSTEMT QDPCGLFQEA YPPLCSSDAA MLRTAHAGET GADEVHLAQY
LIRDASPLRG CLPLPR