MCRI1_BOVIN
ID MCRI1_BOVIN Reviewed; 97 AA.
AC A8E4M4;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Mapk-regulated corepressor-interacting protein 1;
DE AltName: Full=Protein FAM195B;
GN Name=MCRIP1; Synonyms=FAM195B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The phosphorylation status of MCRIP1 functions as a molecular
CC switch to regulate epithelial-mesenchymal transition. Unphosphorylated
CC MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s).
CC When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in
CC transcriptional silencing of the E-cadherin gene and induction of
CC epithelial-mesenchymal transition. {ECO:0000250|UniProtKB:C9JLW8}.
CC -!- SUBUNIT: Interacts (unphosphorylated form, via the PXDLS motif) with
CC CTBP1, competitively inhibiting CTBP-ZEB1 interaction. Interacts with
CC CTBP2. Interacts with MCRIP2 (By similarity). Interacts with DDX6 (By
CC similarity). {ECO:0000250|UniProtKB:C9JLW8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C9JLW8}.
CC Cytoplasm, Stress granule {ECO:0000250|UniProtKB:C9JLW8}.
CC -!- PTM: Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to
CC CTBP(s). {ECO:0000250|UniProtKB:C9JLW8}.
CC -!- SIMILARITY: Belongs to the MCRIP family. {ECO:0000305}.
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DR EMBL; BC149379; AAI49380.1; -; mRNA.
DR RefSeq; NP_001103264.1; NM_001109794.2.
DR AlphaFoldDB; A8E4M4; -.
DR STRING; 9913.ENSBTAP00000049295; -.
DR PaxDb; A8E4M4; -.
DR GeneID; 512391; -.
DR KEGG; bta:512391; -.
DR CTD; 348262; -.
DR eggNOG; ENOG502S25D; Eukaryota.
DR InParanoid; A8E4M4; -.
DR OrthoDB; 1461250at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; ISS:UniProtKB.
DR InterPro; IPR029428; MCRIP.
DR Pfam; PF14799; FAM195; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..97
FT /note="Mapk-regulated corepressor-interacting protein 1"
FT /id="PRO_0000393953"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 80..84
FT /note="PXDLS motif"
FT /evidence="ECO:0000305"
FT COMPBIAS 81..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:C9JLW8"
FT MOD_RES 30
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:C9JLW8"
FT MOD_RES 41
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q3UGS4"
SQ SEQUENCE 97 AA; 11137 MW; 1DFE098DD67A528E CRC64;
MTSSPVSRVV YNGKRNSSHR SPPNSSEIFT PAHEENVRFI YEAWQGVERD LRSQMSGSER
GLVEEYVEKV PNPSLKTFRP IDLSDLKRRN TQDAKKS
