ID   MCR_CHICK               Reviewed;         147 AA.
AC   Q8QHI2;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Mineralocorticoid receptor;
DE            Short=MR;
DE   AltName: Full=Nuclear receptor subfamily 3 group C member 2;
DE   Flags: Fragment;
GN   Name=NR3C2; Synonyms=MLR;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ghavam S., Porter T.E.;
RT   "Cloning of a partial cDNA for the chicken mineralocorticoid receptor.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for both mineralocorticoids (MC) such as aldosterone
CC       and glucocorticoids (GC) such as corticosterone or cortisol. Binds to
CC       mineralocorticoid response elements (MRE) and transactivates target
CC       genes. The effect of MC is to increase ion and water transport and thus
CC       raise extracellular fluid volume and blood pressure and lower potassium
CC       levels (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Cytoplasmic and nuclear in the absence of ligand, nuclear after
CC       ligand-binding. {ECO:0000250}.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
CC       DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF468211; AAL77075.1; -; mRNA.
DR   AlphaFoldDB; Q8QHI2; -.
DR   SMR; Q8QHI2; -.
DR   STRING; 9031.ENSGALP00000016283; -.
DR   PaxDb; Q8QHI2; -.
DR   VEuPathDB; HostDB:geneid_374131; -.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_012534_0_0_1; -.
DR   InParanoid; Q8QHI2; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR   GO; GO:0030518; P:intracellular steroid hormone receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Lipid-binding; Nucleus; Receptor;
KW   Reference proteome; Steroid-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..>147
FT                   /note="Mineralocorticoid receptor"
FT                   /id="PRO_0000053688"
FT   DOMAIN          <1..>147
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   BINDING         6
FT                   /ligand="21-hydroxyprogesterone"
FT                   /ligand_id="ChEBI:CHEBI:16973"
FT                   /evidence="ECO:0000250|UniProtKB:P08235"
FT   BINDING         6
FT                   /ligand="aldosterone"
FT                   /ligand_id="ChEBI:CHEBI:27584"
FT                   /evidence="ECO:0000250|UniProtKB:P08235"
FT   BINDING         6
FT                   /ligand="progesterone"
FT                   /ligand_id="ChEBI:CHEBI:17026"
FT                   /evidence="ECO:0000250|UniProtKB:P08235"
FT   BINDING         134
FT                   /ligand="21-hydroxyprogesterone"
FT                   /ligand_id="ChEBI:CHEBI:16973"
FT                   /evidence="ECO:0000250|UniProtKB:P08235"
FT   BINDING         134
FT                   /ligand="aldosterone"
FT                   /ligand_id="ChEBI:CHEBI:27584"
FT                   /evidence="ECO:0000250|UniProtKB:P08235"
FT   BINDING         134
FT                   /ligand="progesterone"
FT                   /ligand_id="ChEBI:CHEBI:17026"
FT                   /evidence="ECO:0000250|UniProtKB:P08235"
FT   NON_TER         1
FT   NON_TER         147
SQ   SEQUENCE   147 AA;  17424 MW;  152172EE332FF9AD CRC64;
     FALSWRSYKH TNSQFLYFAP DLIFDEERMR QSAMFELCQG MHQISLQFVR LQLSFEEYTI
     MKVLLLLSTV PKDGLKSQAA FEEMRANYIK ELKKMVTKCP SNSGQSWQRF YQLTKLLDSM
     HDLVSDLLEF CFYTFRESQA LKVEFPA