MCS4_SCHPO
ID MCS4_SCHPO Reviewed; 522 AA.
AC P87323; Q9UTZ6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Response regulator mcs4;
DE AltName: Full=Mitotic catastrophe suppressor 4;
GN Name=mcs4; ORFNames=SPBC887.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9383051; DOI=10.1093/genetics/147.3.1043;
RA Cottarel G.;
RT "Mcs4, a two-component system response regulator homologue, regulates the
RT Schizosaccharomyces pombe cell cycle control.";
RL Genetics 147:1043-1051(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=9136929; DOI=10.1101/gad.11.8.1008;
RA Shieh J.C., Wilkinson M.G., Buck V., Morgan B.A., Makino K., Millar J.B.A.;
RT "The Mcs4 response regulator coordinately controls the stress-activated
RT Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.";
RL Genes Dev. 11:1008-1022(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 4-217.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Response regulator that coordinately controls the stress
CC activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell
CC cycle.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR EMBL; AF004694; AAB88257.1; -; Genomic_DNA.
DR EMBL; Y11927; CAA72678.1; -; Genomic_DNA.
DR EMBL; CU329671; CAA21895.1; -; Genomic_DNA.
DR EMBL; AB027909; BAA87213.1; -; Genomic_DNA.
DR PIR; T43417; T43417.
DR RefSeq; NP_596484.1; NM_001022404.2.
DR AlphaFoldDB; P87323; -.
DR SMR; P87323; -.
DR BioGRID; 277723; 25.
DR IntAct; P87323; 2.
DR STRING; 4896.SPBC887.10.1; -.
DR iPTMnet; P87323; -.
DR MaxQB; P87323; -.
DR PaxDb; P87323; -.
DR PRIDE; P87323; -.
DR EnsemblFungi; SPBC887.10.1; SPBC887.10.1:pep; SPBC887.10.
DR GeneID; 2541209; -.
DR KEGG; spo:SPBC887.10; -.
DR PomBase; SPBC887.10; mcs4.
DR VEuPathDB; FungiDB:SPBC887.10; -.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_008307_4_1_1; -.
DR InParanoid; P87323; -.
DR OMA; QALIDWN; -.
DR PhylomeDB; P87323; -.
DR PRO; PR:P87323; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:1990315; C:Mcs4 RR-MAPKKK complex; IDA:PomBase.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IPI:PomBase.
DR GO; GO:0030295; F:protein kinase activator activity; EXP:PomBase.
DR GO; GO:0034599; P:cellular response to oxidative stress; IC:GOC-OWL.
DR GO; GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IDA:PomBase.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IDA:PomBase.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; IMP:PomBase.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Cytoplasm; Phosphoprotein; Reference proteome;
KW Two-component regulatory system.
FT CHAIN 1..522
FT /note="Response regulator mcs4"
FT /id="PRO_0000081407"
FT DOMAIN 363..505
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT REGION 148..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 412
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000305"
SQ SEQUENCE 522 AA; 57240 MW; D99169D301F62460 CRC64;
MRIWFKKVPD GITSSVILSE DHLVDDLKDA IARKFPIRIS QYYDAPELSI RVVAPPNASS
ELQSRELSPN ESILFVMETY YPHGQDFNDA LLVASPDTSV ALRYRSSQLS SSTFESTPPV
FSEYPPNIIP TPANETVPRI KQPSIALDSL ESPVSAPSRH QSTYSYKGGP LNYNLRNASR
TRSHQTLPSS NVNKTGVLLL PRSSRQQTLA SRPSLPDLTS ADKSQPSDEA ESITRKNSIG
MSTRSDESTA EKLAKAEVAT PTNSRSISHS SLYTKQSGTA GVLPAVNADI DAANRMNPDI
SSQFPIADNK DPLNADTQAH LGFPSNQIDG IVGTSPVNVL TSPGIGAKAP FASLLEGVIP
PINVLIVEDN IINQKILETF MKKRNISSEV AKDGLEALEK WKKKSFHLIL MDIQLPTMSG
IEVTQEIRRL ERLNAIGVGA PKLTQPIPEK DQLNENKFQS PVIIVALTAS SLMADRNEAL
AAGCNDFLTK PVSLVWLEKK ITEWGCMQAL IDWNGWCRFR GR
