MCSP_HUMAN
ID MCSP_HUMAN Reviewed; 116 AA.
AC P49901; Q96A42;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2002, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Sperm mitochondrial-associated cysteine-rich protein;
GN Name=SMCP; Synonyms=MCS, MCSP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Testis;
RX PubMed=8833144; DOI=10.1006/geno.1996.0104;
RA Aho H., Schwemmer M., Tessmann D., Murphy D., Mattei M.-G., Engel W.,
RA Adham I.M.;
RT "Isolation, expression, and chromosomal localization of the human
RT mitochondrial capsule selenoprotein gene (MCSP).";
RL Genomics 32:184-190(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in sperm motility. Its absence is associated with
CC genetic background dependent male infertility. Infertility may be due
CC to reduced sperm motility in the female reproductive tract and
CC inability to penetrate the oocyte zona pellucida (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC P49901; P05187: ALPP; NbExp=3; IntAct=EBI-750494, EBI-1211484;
CC P49901; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-750494, EBI-725606;
CC P49901; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-750494, EBI-739580;
CC P49901; P0DN86: CGB3; NbExp=3; IntAct=EBI-750494, EBI-8626304;
CC P49901; O75638-2: CTAG2; NbExp=3; IntAct=EBI-750494, EBI-12265122;
CC P49901; A8MQ03: CYSRT1; NbExp=6; IntAct=EBI-750494, EBI-3867333;
CC P49901; P63167: DYNLL1; NbExp=9; IntAct=EBI-750494, EBI-349105;
CC P49901; Q96FJ2: DYNLL2; NbExp=3; IntAct=EBI-750494, EBI-742371;
CC P49901; Q08379: GOLGA2; NbExp=3; IntAct=EBI-750494, EBI-618309;
CC P49901; P28799: GRN; NbExp=3; IntAct=EBI-750494, EBI-747754;
CC P49901; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-750494, EBI-11978177;
CC P49901; P24592: IGFBP6; NbExp=3; IntAct=EBI-750494, EBI-947015;
CC P49901; Q15323: KRT31; NbExp=6; IntAct=EBI-750494, EBI-948001;
CC P49901; O76011: KRT34; NbExp=3; IntAct=EBI-750494, EBI-1047093;
CC P49901; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-750494, EBI-11959885;
CC P49901; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-750494, EBI-11749135;
CC P49901; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-750494, EBI-11741292;
CC P49901; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-750494, EBI-10217483;
CC P49901; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-750494, EBI-10172150;
CC P49901; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-750494, EBI-10172290;
CC P49901; P60410: KRTAP10-8; NbExp=9; IntAct=EBI-750494, EBI-10171774;
CC P49901; P60411: KRTAP10-9; NbExp=8; IntAct=EBI-750494, EBI-10172052;
CC P49901; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-750494, EBI-10210845;
CC P49901; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-750494, EBI-10176396;
CC P49901; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-750494, EBI-11957260;
CC P49901; Q9BYQ6: KRTAP4-11; NbExp=6; IntAct=EBI-750494, EBI-10302392;
CC P49901; Q9BQ66: KRTAP4-12; NbExp=11; IntAct=EBI-750494, EBI-739863;
CC P49901; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-750494, EBI-10172511;
CC P49901; Q9BYR3: KRTAP4-4; NbExp=6; IntAct=EBI-750494, EBI-11958132;
CC P49901; Q9BYR2: KRTAP4-5; NbExp=5; IntAct=EBI-750494, EBI-11993254;
CC P49901; Q9BYR0: KRTAP4-7; NbExp=3; IntAct=EBI-750494, EBI-10302547;
CC P49901; Q6L8G4: KRTAP5-11; NbExp=5; IntAct=EBI-750494, EBI-11993296;
CC P49901; Q701N4: KRTAP5-2; NbExp=6; IntAct=EBI-750494, EBI-11958178;
CC P49901; Q6L8H2: KRTAP5-3; NbExp=5; IntAct=EBI-750494, EBI-11974251;
CC P49901; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-750494, EBI-11963072;
CC P49901; Q6L8G9: KRTAP5-6; NbExp=8; IntAct=EBI-750494, EBI-10250562;
CC P49901; P26371: KRTAP5-9; NbExp=8; IntAct=EBI-750494, EBI-3958099;
CC P49901; Q9BYQ4: KRTAP9-2; NbExp=8; IntAct=EBI-750494, EBI-1044640;
CC P49901; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-750494, EBI-1043191;
CC P49901; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-750494, EBI-10185730;
CC P49901; Q9BYQ0: KRTAP9-8; NbExp=6; IntAct=EBI-750494, EBI-11958364;
CC P49901; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-750494, EBI-11962058;
CC P49901; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-750494, EBI-10245913;
CC P49901; Q5T752: LCE1D; NbExp=3; IntAct=EBI-750494, EBI-11741311;
CC P49901; Q5T753: LCE1E; NbExp=3; IntAct=EBI-750494, EBI-11955335;
CC P49901; Q5T754: LCE1F; NbExp=3; IntAct=EBI-750494, EBI-11958008;
CC P49901; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-750494, EBI-11973993;
CC P49901; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-750494, EBI-10246750;
CC P49901; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-750494, EBI-9394625;
CC P49901; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-750494, EBI-11974495;
CC P49901; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-750494, EBI-10246358;
CC P49901; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-750494, EBI-11955689;
CC P49901; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-750494, EBI-2683507;
CC P49901; P07438: MT1B; NbExp=3; IntAct=EBI-750494, EBI-12015462;
CC P49901; Q8N339: MT1M; NbExp=3; IntAct=EBI-750494, EBI-3911571;
CC P49901; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-750494, EBI-945833;
CC P49901; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-750494, EBI-22310682;
CC P49901; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-750494, EBI-11956269;
CC P49901; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-750494, EBI-949255;
CC P49901; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-750494, EBI-750734;
CC P49901; Q86WC6: PPP1R27; NbExp=3; IntAct=EBI-750494, EBI-5235602;
CC P49901; P30044: PRDX5; NbExp=3; IntAct=EBI-750494, EBI-722161;
CC P49901; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-750494, EBI-3918154;
CC P49901; Q92504: SLC39A7; NbExp=3; IntAct=EBI-750494, EBI-1051105;
CC P49901; O43609: SPRY1; NbExp=3; IntAct=EBI-750494, EBI-3866665;
CC P49901; P15884: TCF4; NbExp=3; IntAct=EBI-750494, EBI-533224;
CC P49901; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-750494, EBI-5235829;
CC P49901; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-750494, EBI-607755;
CC P49901; Q6EMK4: VASN; NbExp=3; IntAct=EBI-750494, EBI-10249550;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion membrane {ECO:0000305};
CC Peripheral membrane protein {ECO:0000305}; Cytoplasmic side
CC {ECO:0000305}. Note=Becomes associated with the spermatid mitochondrion
CC capsule at step 16 of spermatogenesis. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis. Is selectively expressed in the spermatids
CC of seminiferous tubules. {ECO:0000269|PubMed:8833144}.
CC -!- DEVELOPMENTAL STAGE: Expressed in postmeiotic cells.
CC {ECO:0000269|PubMed:8833144}.
CC -!- CAUTION: Was originally thought to be a selenoprotein and was known as
CC sperm mitochondrial capsule selenoprotein.
CC {ECO:0000305|PubMed:8833144}.
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DR EMBL; X89960; CAA62000.1; -; mRNA.
DR EMBL; X89961; CAD56487.1; -; Genomic_DNA.
DR EMBL; BC014593; AAH14593.1; -; mRNA.
DR EMBL; BC016744; AAH16744.1; -; mRNA.
DR CCDS; CCDS1029.1; -.
DR RefSeq; NP_109588.2; NM_030663.2.
DR AlphaFoldDB; P49901; -.
DR BioGRID; 110350; 78.
DR IntAct; P49901; 70.
DR STRING; 9606.ENSP00000357754; -.
DR PhosphoSitePlus; P49901; -.
DR BioMuta; SMCP; -.
DR MassIVE; P49901; -.
DR PaxDb; P49901; -.
DR PeptideAtlas; P49901; -.
DR PRIDE; P49901; -.
DR ProteomicsDB; 56173; -.
DR Antibodypedia; 34107; 213 antibodies from 22 providers.
DR DNASU; 4184; -.
DR Ensembl; ENST00000368765.4; ENSP00000357754.3; ENSG00000163206.6.
DR GeneID; 4184; -.
DR KEGG; hsa:4184; -.
DR MANE-Select; ENST00000368765.4; ENSP00000357754.3; NM_030663.3; NP_109588.2.
DR CTD; 4184; -.
DR DisGeNET; 4184; -.
DR GeneCards; SMCP; -.
DR HGNC; HGNC:6962; SMCP.
DR HPA; ENSG00000163206; Tissue enriched (testis).
DR MIM; 601148; gene.
DR neXtProt; NX_P49901; -.
DR OpenTargets; ENSG00000163206; -.
DR PharmGKB; PA30710; -.
DR VEuPathDB; HostDB:ENSG00000163206; -.
DR eggNOG; ENOG502TDSM; Eukaryota.
DR GeneTree; ENSGT00440000039991; -.
DR HOGENOM; CLU_169086_0_0_1; -.
DR InParanoid; P49901; -.
DR OMA; QPKCPQC; -.
DR OrthoDB; 1548594at2759; -.
DR PhylomeDB; P49901; -.
DR PathwayCommons; P49901; -.
DR SignaLink; P49901; -.
DR BioGRID-ORCS; 4184; 12 hits in 1072 CRISPR screens.
DR ChiTaRS; SMCP; human.
DR GeneWiki; SMCP; -.
DR GenomeRNAi; 4184; -.
DR Pharos; P49901; Tbio.
DR PRO; PR:P49901; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; P49901; protein.
DR Bgee; ENSG00000163206; Expressed in sperm and 112 other tissues.
DR ExpressionAtlas; P49901; baseline and differential.
DR Genevisible; P49901; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0007341; P:penetration of zona pellucida; ISS:UniProtKB.
DR InterPro; IPR039347; SMCP.
DR PANTHER; PTHR35820; PTHR35820; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Fertilization; Membrane; Mitochondrion; Reference proteome;
KW Repeat.
FT CHAIN 1..116
FT /note="Sperm mitochondrial-associated cysteine-rich
FT protein"
FT /id="PRO_0000096307"
FT REPEAT 6..13
FT /note="1"
FT REPEAT 14..21
FT /note="2"
FT REPEAT 30..37
FT /note="3"
FT REPEAT 38..45
FT /note="4"
FT REPEAT 46..53
FT /note="5"
FT REPEAT 54..61
FT /note="6"
FT REPEAT 62..68
FT /note="7"
FT REGION 6..68
FT /note="7 X 7 (OR 8) AA approximate repeats"
FT REGION 80..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 63
FT /note="P -> A (in Ref. 1; CAA62000/CAD56487)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 116 AA; 12767 MW; 242191C60AEE03B2 CRC64;
MCDQTKHSKC CPAKGNQCCP PQQNQCCQSK GNQCCPPKQN QCCQPKGSQC CPPKHNHCCQ
PKPPCCIQAR CCGLETKPEV SPLNMESEPN SPQTQDKGCQ TQQQPHSPQN ESRPSK
