ID   MCTB_MYCBO              Reviewed;         314 AA.
AC   P64884; A0A1R3XZ43; P58212; X2BIW3;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Copper transporter MctB;
DE   Flags: Precursor;
GN   Name=mctB; OrderedLocusNames=BQ2027_MB1724;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Pore-forming protein, which is involved in efflux of copper
CC       across the outer membrane. Essential for copper resistance and
CC       maintenance of a low intracellular copper concentration (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MctB (TC 1.B.50) family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU00328.1; -; Genomic_DNA.
DR   RefSeq; NP_855377.1; NC_002945.3.
DR   RefSeq; WP_003408390.1; NC_002945.4.
DR   AlphaFoldDB; P64884; -.
DR   EnsemblBacteria; SIU00328; SIU00328; BQ2027_MB1724.
DR   PATRIC; fig|233413.5.peg.1880; -.
DR   OMA; FRYHIVS; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0055070; P:copper ion homeostasis; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR021522; MctB.
DR   Pfam; PF11382; MctB; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Copper; Ion transport; Membrane; Porin; Signal;
KW   Transmembrane; Transport.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..314
FT                   /note="Copper transporter MctB"
FT                   /id="PRO_0000014106"
SQ   SEQUENCE   314 AA;  32391 MW;  9B45A61E10F78339 CRC64;
     MISLRQHAVS LAAVFLALAM GVVLGSGFFS DTLLSSLRSE KRDLYTQIDR LTDQRDALRE
     KLSAADNFDI QVGSRIVHDA LVGKSVVIFR TPDAHDDDIA AVSKIVGQAG GAVTATVSLT
     QEFVEANSAE KLRSVVNSSI LPAGSQLSTK LVDQGSQAGD LLGIALLSNA DPAAPTVEQA
     QRDTVLAALR ETGFITYQPR DRIGTANATV VVTGGALSTD AGNQGVSVAR FAAALAPRGS
     GTLLAGRDGS ANRPAAVAVT RADADMAAEI STVDDIDAEP GRITVILALH DLINGGHVGH
     YGTGHGAMSV TVSQ