ID   MCTB_MYCTO              Reviewed;         314 AA.
AC   P9WJ82; L0TAD1; P58212; P64883;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Copper transporter MctB;
DE   AltName: Full=Mycobacterial copper transport protein B;
DE   Flags: Precursor;
GN   Name=mctB; OrderedLocusNames=MT1737;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Pore-forming protein, which is involved in efflux of copper
CC       across the outer membrane. Essential for copper resistance and
CC       maintenance of a low intracellular copper concentration. Required for
CC       virulence (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MctB (TC 1.B.50) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46006.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK46006.1; ALT_INIT; Genomic_DNA.
DR   PIR; A70503; A70503.
DR   RefSeq; WP_003408390.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJ82; -.
DR   EnsemblBacteria; AAK46006; AAK46006; MT1737.
DR   KEGG; mtc:MT1737; -.
DR   PATRIC; fig|83331.31.peg.1865; -.
DR   HOGENOM; CLU_072020_0_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0055070; P:copper ion homeostasis; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR021522; MctB.
DR   Pfam; PF11382; MctB; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Copper; Ion transport; Membrane; Porin; Signal;
KW   Transmembrane; Transport.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..314
FT                   /note="Copper transporter MctB"
FT                   /id="PRO_0000427875"
SQ   SEQUENCE   314 AA;  32391 MW;  9B45A61E10F78339 CRC64;
     MISLRQHAVS LAAVFLALAM GVVLGSGFFS DTLLSSLRSE KRDLYTQIDR LTDQRDALRE
     KLSAADNFDI QVGSRIVHDA LVGKSVVIFR TPDAHDDDIA AVSKIVGQAG GAVTATVSLT
     QEFVEANSAE KLRSVVNSSI LPAGSQLSTK LVDQGSQAGD LLGIALLSNA DPAAPTVEQA
     QRDTVLAALR ETGFITYQPR DRIGTANATV VVTGGALSTD AGNQGVSVAR FAAALAPRGS
     GTLLAGRDGS ANRPAAVAVT RADADMAAEI STVDDIDAEP GRITVILALH DLINGGHVGH
     YGTGHGAMSV TVSQ