ID   MCTS1_CHICK             Reviewed;         181 AA.
AC   Q5ZI42;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Malignant T-cell-amplified sequence 1;
DE            Short=MCT-1;
GN   Name=MCTS1; ORFNames=RCJMB04_30h12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Plays a role as translation enhancer and involved in cell
CC       cycle regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The PUA RNA-binding domain is critical for cap binding, but not
CC       sufficient for translation enhancer function. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MCTS1 family. {ECO:0000305}.
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DR   EMBL; AJ720942; CAG32601.1; -; mRNA.
DR   RefSeq; NP_001099145.1; NM_001105675.1.
DR   AlphaFoldDB; Q5ZI42; -.
DR   SMR; Q5ZI42; -.
DR   STRING; 9031.ENSGALP00000013855; -.
DR   PaxDb; Q5ZI42; -.
DR   Ensembl; ENSGALT00000013871; ENSGALP00000013855; ENSGALG00000008517.
DR   GeneID; 422363; -.
DR   KEGG; gga:422363; -.
DR   CTD; 28985; -.
DR   VEuPathDB; HostDB:geneid_422363; -.
DR   eggNOG; KOG2523; Eukaryota.
DR   GeneTree; ENSGT00550000074964; -.
DR   HOGENOM; CLU_090468_0_1_1; -.
DR   InParanoid; Q5ZI42; -.
DR   OMA; HDHIEIL; -.
DR   OrthoDB; 1257440at2759; -.
DR   PhylomeDB; Q5ZI42; -.
DR   TreeFam; TF315123; -.
DR   PRO; PR:Q5ZI42; -.
DR   Proteomes; UP000000539; Chromosome 4.
DR   Bgee; ENSGALG00000008517; Expressed in skeletal muscle tissue and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR016437; MCT-1/Tma20.
DR   InterPro; IPR041366; Pre-PUA.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   PANTHER; PTHR22798; PTHR22798; 1.
DR   Pfam; PF17832; Pre-PUA; 1.
DR   Pfam; PF01472; PUA; 1.
DR   PIRSF; PIRSF005067; Tma_RNA-bind_prd; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Growth regulation; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..181
FT                   /note="Malignant T-cell-amplified sequence 1"
FT                   /id="PRO_0000344790"
FT   DOMAIN          92..171
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
SQ   SEQUENCE   181 AA;  20571 MW;  7BA0F4C3A51055CD CRC64;
     MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI DQFPVIEPWL NQIMPKKDPV KIVRCHEHIE
     ILTVNGELLF FRQREGIFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG
     AKLYPAAVDT VVAIMAEGKQ HALCVGVMKM SADDIEKVNK GIGIENIHYL NDGLWHMKTY
     K