ID   MCTS1_DICDI             Reviewed;         182 AA.
AC   Q86KL4; Q55AD8;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Malignant T-cell-amplified sequence 1 homolog;
DE            Short=MCT-1;
GN   Name=mcts1; ORFNames=DDB_G0271910;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May play a role in cell cycle regulation. May play a role as
CC       translation enhancer by binding to the cap complex of the 5'-terminus
CC       of mRNAs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The PUA RNA-binding domain is critical for cap binding, but not
CC       sufficient for translation enhancer function. MCT1 N-terminal region is
CC       required to enhance translation possibly through interaction with other
CC       proteins (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MCTS1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000007; EAL71479.1; -; Genomic_DNA.
DR   RefSeq; XP_645418.1; XM_640326.1.
DR   AlphaFoldDB; Q86KL4; -.
DR   SMR; Q86KL4; -.
DR   STRING; 44689.DDB0168553; -.
DR   PaxDb; Q86KL4; -.
DR   EnsemblProtists; EAL71479; EAL71479; DDB_G0271910.
DR   GeneID; 8618202; -.
DR   KEGG; ddi:DDB_G0271910; -.
DR   dictyBase; DDB_G0271910; -.
DR   eggNOG; KOG2523; Eukaryota.
DR   HOGENOM; CLU_090468_0_1_1; -.
DR   InParanoid; Q86KL4; -.
DR   OMA; HDHIEIL; -.
DR   PhylomeDB; Q86KL4; -.
DR   PRO; PR:Q86KL4; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   InterPro; IPR016437; MCT-1/Tma20.
DR   InterPro; IPR041366; Pre-PUA.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   PANTHER; PTHR22798; PTHR22798; 1.
DR   Pfam; PF17832; Pre-PUA; 1.
DR   Pfam; PF01472; PUA; 1.
DR   PIRSF; PIRSF005067; Tma_RNA-bind_prd; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cytoplasm; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..182
FT                   /note="Malignant T-cell-amplified sequence 1 homolog"
FT                   /id="PRO_0000349103"
FT   DOMAIN          92..172
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
SQ   SEQUENCE   182 AA;  20422 MW;  96731460D8CDA513 CRC64;
     MFKKLSLKGS SNTNNQIKSS LQRNIKNSIL AQYPKLKDIE EDVFPKKVPI VQVKCQNHIN
     LVLINNEVLF FNEREGPYYP TLRFLHKYPN ILPHVQVDKG AIKFVLQGAN IMCRGLTSPG
     AKMEVDLPVD AIVAVMAEGK DHASAIGVMK MSTNDIRTIN NDIGINNIHY LGDSLYMSPN
     LE