ID   MCTS1_XENTR             Reviewed;         181 AA.
AC   Q6DER1;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Malignant T-cell-amplified sequence 1;
DE            Short=MCT-1;
GN   Name=mcts1; ORFNames=TEgg094c21.2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role as translation enhancer and involved in cell
CC       cycle regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The PUA RNA-binding domain is critical for cap binding, but not
CC       sufficient for translation enhancer function. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MCTS1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR761407; CAJ82207.1; -; mRNA.
DR   EMBL; BC077034; AAH77034.1; -; mRNA.
DR   RefSeq; NP_001006880.1; NM_001006879.1.
DR   AlphaFoldDB; Q6DER1; -.
DR   SMR; Q6DER1; -.
DR   STRING; 8364.ENSXETP00000009702; -.
DR   PaxDb; Q6DER1; -.
DR   DNASU; 448679; -.
DR   GeneID; 448679; -.
DR   KEGG; xtr:448679; -.
DR   CTD; 28985; -.
DR   Xenbase; XB-GENE-998581; mcts1.
DR   eggNOG; KOG2523; Eukaryota.
DR   HOGENOM; CLU_090468_0_1_1; -.
DR   InParanoid; Q6DER1; -.
DR   OMA; HDHIEIL; -.
DR   OrthoDB; 1257440at2759; -.
DR   PhylomeDB; Q6DER1; -.
DR   TreeFam; TF315123; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004472; Expressed in egg cell and 15 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR016437; MCT-1/Tma20.
DR   InterPro; IPR041366; Pre-PUA.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   PANTHER; PTHR22798; PTHR22798; 1.
DR   Pfam; PF17832; Pre-PUA; 1.
DR   Pfam; PF01472; PUA; 1.
DR   PIRSF; PIRSF005067; Tma_RNA-bind_prd; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Growth regulation; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..181
FT                   /note="Malignant T-cell-amplified sequence 1"
FT                   /id="PRO_0000344794"
FT   DOMAIN          92..171
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
SQ   SEQUENCE   181 AA;  20558 MW;  1906DC7C99FB62E6 CRC64;
     MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI DQFPVIEQWL NQIMPKKDPV KIVRCHEHIE
     ILTVNGELLF FRQREGPFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG
     AKLYPAAADT VVAIMAEGKQ HALCVGVMKM SADDIEKVNK GIGIENIHYL NDGLWHMKTY
     K