ID   MCTS2_HUMAN             Reviewed;         181 AA.
AC   A0A3B3IRV3;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2018, sequence version 1.
DT   03-AUG-2022, entry version 15.
DE   RecName: Full=Malignant T-cell-amplified sequence 2 {ECO:0000305};
GN   Name=MCTS2 {ECO:0000312|HGNC:HGNC:49760};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2]
RP   IMPRINTING, AND MISCELLANEOUS.
RX   PubMed=17291163; DOI=10.1371/journal.pgen.0030020;
RA   Wood A.J., Roberts R.G., Monk D., Moore G.E., Schulz R., Oakey R.J.;
RT   "A screen for retrotransposed imprinted genes reveals an association
RT   between X chromosome homology and maternal germ-line methylation.";
RL   PLoS Genet. 3:e20-e20(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ULC4}.
CC   -!- MISCELLANEOUS: Imprinted gene expressed from the paternal allele in
CC       fetal spinal cord. {ECO:0000305|PubMed:17291163}.
CC   -!- SIMILARITY: Belongs to the MCTS1 family. {ECO:0000305}.
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DR   EMBL; AL110115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A3B3IRV3; -.
DR   SMR; A0A3B3IRV3; -.
DR   Ensembl; ENST00000394552.3; ENSP00000496921.1; ENSG00000101898.6.
DR   MANE-Select; ENST00000394552.4; ENSP00000496921.1; NM_001397496.1; NP_001384425.1.
DR   GeneCards; MCTS2P; -.
DR   HGNC; HGNC:49760; MCTS2.
DR   VEuPathDB; HostDB:ENSG00000101898; -.
DR   GeneTree; ENSGT00550000074964; -.
DR   OMA; MFKKFSP; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000101898; Expressed in cortical plate and 95 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   InterPro; IPR016437; MCT-1/Tma20.
DR   InterPro; IPR041366; Pre-PUA.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   PANTHER; PTHR22798; PTHR22798; 1.
DR   Pfam; PF17832; Pre-PUA; 1.
DR   Pfam; PF01472; PUA; 1.
DR   PIRSF; PIRSF005067; Tma_RNA-bind_prd; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF88697; SSF88697; 1.
DR   TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..181
FT                   /note="Malignant T-cell-amplified sequence 2"
FT                   /id="PRO_0000455534"
FT   DOMAIN          92..171
FT                   /note="PUA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
SQ   SEQUENCE   181 AA;  20343 MW;  6603F701DDE4B304 CRC64;
     MFKKFDEKES VSNCIQLKTS VIKGIKSQLV EQFPGIEPWL NQIMPKKDPV KIVRCHEHTE
     ILTVSGELLF FRQRKGPFCP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG
     AKLYPAAVDT IVAVTAEGKQ HALCVGVMKM SAEDIEKVNK GIGIENIHYL NDGLWHMKTY
     K