MCTS2_MOUSE
ID MCTS2_MOUSE Reviewed; 181 AA.
AC Q9CQ21;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Malignant T-cell-amplified sequence 2 {ECO:0000305};
DE Short=MCT-2;
DE AltName: Full=Multiple copies T-cell malignancies 2;
GN Name=Mcts2 {ECO:0000312|MGI:MGI:1913655};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IMPRINTING, AND MISCELLANEOUS.
RX PubMed=18024232; DOI=10.1016/j.modgep.2007.09.005;
RA Kuzmin A., Han Z., Golding M.C., Mann M.R., Latham K.E., Varmuza S.;
RT "The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues.";
RL Gene Expr. Patterns 8:107-116(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ULC4}.
CC -!- MISCELLANEOUS: Imprinted gene expressed from the paternal allele in
CC blastocysts. {ECO:0000305|PubMed:18024232}.
CC -!- SIMILARITY: Belongs to the MCTS1 family. {ECO:0000305}.
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DR EMBL; AK002563; BAB22189.1; -; mRNA.
DR EMBL; AK010255; BAB26798.1; -; mRNA.
DR EMBL; AK028001; BAC25695.1; -; mRNA.
DR EMBL; AL845162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027507; AAH27507.1; -; mRNA.
DR CCDS; CCDS38281.1; -.
DR RefSeq; NP_079819.1; NM_025543.2.
DR AlphaFoldDB; Q9CQ21; -.
DR SMR; Q9CQ21; -.
DR BioGRID; 211449; 2.
DR IntAct; Q9CQ21; 1.
DR MINT; Q9CQ21; -.
DR STRING; 10090.ENSMUSP00000100534; -.
DR SwissPalm; Q9CQ21; -.
DR MaxQB; Q9CQ21; -.
DR PaxDb; Q9CQ21; -.
DR PeptideAtlas; Q9CQ21; -.
DR PRIDE; Q9CQ21; -.
DR ProteomicsDB; 292202; -.
DR DNASU; 66405; -.
DR Ensembl; ENSMUST00000062148; ENSMUSP00000100534; ENSMUSG00000042814.
DR GeneID; 66405; -.
DR KEGG; mmu:66405; -.
DR UCSC; uc008nge.1; mouse.
DR CTD; 100101490; -.
DR MGI; MGI:1913655; Mcts2.
DR VEuPathDB; HostDB:ENSMUSG00000042814; -.
DR eggNOG; KOG2523; Eukaryota.
DR GeneTree; ENSGT00550000074964; -.
DR HOGENOM; CLU_090468_0_1_1; -.
DR InParanoid; Q9CQ21; -.
DR OMA; KEHALCV; -.
DR OrthoDB; 1257440at2759; -.
DR PhylomeDB; Q9CQ21; -.
DR TreeFam; TF315123; -.
DR BioGRID-ORCS; 66405; 4 hits in 74 CRISPR screens.
DR PRO; PR:Q9CQ21; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CQ21; protein.
DR Bgee; ENSMUSG00000042814; Expressed in floor plate of midbrain and 244 other tissues.
DR Genevisible; Q9CQ21; MM.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001731; P:formation of translation preinitiation complex; ISO:MGI.
DR GO; GO:0075522; P:IRES-dependent viral translational initiation; ISO:MGI.
DR GO; GO:0032790; P:ribosome disassembly; ISO:MGI.
DR InterPro; IPR016437; MCT-1/Tma20.
DR InterPro; IPR041366; Pre-PUA.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR004521; Uncharacterised_CHP00451.
DR PANTHER; PTHR22798; PTHR22798; 1.
DR Pfam; PF17832; Pre-PUA; 1.
DR Pfam; PF01472; PUA; 1.
DR PIRSF; PIRSF005067; Tma_RNA-bind_prd; 1.
DR SMART; SM00359; PUA; 1.
DR SUPFAM; SSF88697; SSF88697; 1.
DR TIGRFAMs; TIGR00451; unchar_dom_2; 1.
DR PROSITE; PS50890; PUA; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..181
FT /note="Malignant T-cell-amplified sequence 2"
FT /id="PRO_0000344788"
FT DOMAIN 92..171
FT /note="PUA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00161"
SQ SEQUENCE 181 AA; 20437 MW; D549F69DE8E693C2 CRC64;
MFKKFDEKES VSNCIQLKTS VIKGIKSQLT EQFPGIEPWL NQIMPKKDPV KIVRCHEHME
ILTVNGELLF FRQRKGPFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG
AKLYTAAVDT IVAVMAEGKE HALCVGVMKM AAADIEKINK GIGIENIHYL NDGLWHMKTY
K
