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MCU4_ARATH
ID   MCU4_ARATH              Reviewed;         293 AA.
AC   Q9FJV7;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Calcium uniporter protein 4, mitochondrial;
DE   Flags: Precursor;
GN   OrderedLocusNames=At5g42610 {ECO:0000312|Araport:AT5G42610};
GN   ORFNames=MFO20.2 {ECO:0000312|EMBL:BAB10499.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA   Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT   features of the regions of 1,367,185 bp covered by 19 physically assigned
RT   P1 and TAC clones.";
RL   DNA Res. 5:203-216(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Xiao Y.-L., Underwood B.A., Moskal W.A. Jr., Wang W., Redman J.C., Wu H.C.,
RA   Utterback T., Town C.D.;
RT   "Reconstruction of cDNA sequences for hypothetical genes in Arabidopsis
RT   thaliana from 5' and 3' RACE products.";
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND REVIEW.
RX   PubMed=22200666; DOI=10.1093/jxb/err394;
RA   Stael S., Wurzinger B., Mair A., Mehlmer N., Vothknecht U.C., Teige M.;
RT   "Plant organellar calcium signalling: an emerging field.";
RL   J. Exp. Bot. 63:1525-1542(2012).
CC   -!- FUNCTION: Mitochondrial inner membrane calcium uniporter that mediates
CC       calcium uptake into mitochondria. Constitutes a pore-forming and
CC       calcium-conducting subunit. Mitochondrial calcium homeostasis plays key
CC       roles in cellular physiology and regulates cell bioenergetics,
CC       cytoplasmic calcium signals and activation of cell death pathways.
CC       {ECO:0000250|UniProtKB:Q8NE86}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q8NE86}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q8NE86}.
CC   -!- SIMILARITY: Belongs to the MCU (TC 1.A.77) family. {ECO:0000305}.
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DR   EMBL; AB013391; BAB10499.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94835.1; -; Genomic_DNA.
DR   EMBL; AY735694; AAU44564.1; -; mRNA.
DR   EMBL; AY773901; AAV63930.1; -; mRNA.
DR   RefSeq; NP_199075.1; NM_123625.4.
DR   AlphaFoldDB; Q9FJV7; -.
DR   SMR; Q9FJV7; -.
DR   STRING; 3702.AT5G42610.1; -.
DR   PaxDb; Q9FJV7; -.
DR   PRIDE; Q9FJV7; -.
DR   EnsemblPlants; AT5G42610.1; AT5G42610.1; AT5G42610.
DR   GeneID; 834268; -.
DR   Gramene; AT5G42610.1; AT5G42610.1; AT5G42610.
DR   KEGG; ath:AT5G42610; -.
DR   Araport; AT5G42610; -.
DR   TAIR; locus:2163842; AT5G42610.
DR   eggNOG; KOG2966; Eukaryota.
DR   HOGENOM; CLU_066330_0_0_1; -.
DR   InParanoid; Q9FJV7; -.
DR   OMA; SCGNDEQ; -.
DR   OrthoDB; 1076768at2759; -.
DR   PhylomeDB; Q9FJV7; -.
DR   PRO; PR:Q9FJV7; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FJV7; baseline and differential.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:1990246; C:uniplex complex; IBA:GO_Central.
DR   GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR   GO; GO:0015292; F:uniporter activity; IBA:GO_Central.
DR   GO; GO:0036444; P:calcium import into the mitochondrion; IBA:GO_Central.
DR   GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR006769; MCU_C.
DR   InterPro; IPR039055; MCU_fam.
DR   PANTHER; PTHR13462; PTHR13462; 1.
DR   Pfam; PF04678; MCU; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix; Transport.
FT   TRANSIT         1..5
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           6..293
FT                   /note="Calcium uniporter protein 4, mitochondrial"
FT                   /id="PRO_0000431373"
FT   TRANSMEM        189..209
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   293 AA;  34260 MW;  8AF24707C9652990 CRC64;
     MALRRAITKR LIDCYRSDVT QQHSFFRQLS PYNMKIHRQY MTSPNGPNLT DRIVGIRIES
     VSPPRREETP VMGLSVSETK KLLRLYQMEK VKERLREIPK SSVSYWEFIQ ICCESCGNDE
     QGSQMAKSLD HSGCVVVLGD IVFLHPHQIA KSMEAMIKQT SVLPNDPRKE ELVQLATTKK
     SIDIEARRIV QAELYCGLGF LAVQTIGFMR LTFWELSWDV MEPICFFVTT IHFILGYIFF
     LRTSTEPSFE GLFRQRFKTK QKKLMERHGF DFLRYNELNS LFTTFPCKFH YPV
 
 
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