MCU4_ARATH
ID MCU4_ARATH Reviewed; 293 AA.
AC Q9FJV7;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Calcium uniporter protein 4, mitochondrial;
DE Flags: Precursor;
GN OrderedLocusNames=At5g42610 {ECO:0000312|Araport:AT5G42610};
GN ORFNames=MFO20.2 {ECO:0000312|EMBL:BAB10499.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Xiao Y.-L., Underwood B.A., Moskal W.A. Jr., Wang W., Redman J.C., Wu H.C.,
RA Utterback T., Town C.D.;
RT "Reconstruction of cDNA sequences for hypothetical genes in Arabidopsis
RT thaliana from 5' and 3' RACE products.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND REVIEW.
RX PubMed=22200666; DOI=10.1093/jxb/err394;
RA Stael S., Wurzinger B., Mair A., Mehlmer N., Vothknecht U.C., Teige M.;
RT "Plant organellar calcium signalling: an emerging field.";
RL J. Exp. Bot. 63:1525-1542(2012).
CC -!- FUNCTION: Mitochondrial inner membrane calcium uniporter that mediates
CC calcium uptake into mitochondria. Constitutes a pore-forming and
CC calcium-conducting subunit. Mitochondrial calcium homeostasis plays key
CC roles in cellular physiology and regulates cell bioenergetics,
CC cytoplasmic calcium signals and activation of cell death pathways.
CC {ECO:0000250|UniProtKB:Q8NE86}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q8NE86}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q8NE86}.
CC -!- SIMILARITY: Belongs to the MCU (TC 1.A.77) family. {ECO:0000305}.
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DR EMBL; AB013391; BAB10499.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94835.1; -; Genomic_DNA.
DR EMBL; AY735694; AAU44564.1; -; mRNA.
DR EMBL; AY773901; AAV63930.1; -; mRNA.
DR RefSeq; NP_199075.1; NM_123625.4.
DR AlphaFoldDB; Q9FJV7; -.
DR SMR; Q9FJV7; -.
DR STRING; 3702.AT5G42610.1; -.
DR PaxDb; Q9FJV7; -.
DR PRIDE; Q9FJV7; -.
DR EnsemblPlants; AT5G42610.1; AT5G42610.1; AT5G42610.
DR GeneID; 834268; -.
DR Gramene; AT5G42610.1; AT5G42610.1; AT5G42610.
DR KEGG; ath:AT5G42610; -.
DR Araport; AT5G42610; -.
DR TAIR; locus:2163842; AT5G42610.
DR eggNOG; KOG2966; Eukaryota.
DR HOGENOM; CLU_066330_0_0_1; -.
DR InParanoid; Q9FJV7; -.
DR OMA; SCGNDEQ; -.
DR OrthoDB; 1076768at2759; -.
DR PhylomeDB; Q9FJV7; -.
DR PRO; PR:Q9FJV7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJV7; baseline and differential.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:1990246; C:uniplex complex; IBA:GO_Central.
DR GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR GO; GO:0015292; F:uniporter activity; IBA:GO_Central.
DR GO; GO:0036444; P:calcium import into the mitochondrion; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IBA:GO_Central.
DR InterPro; IPR006769; MCU_C.
DR InterPro; IPR039055; MCU_fam.
DR PANTHER; PTHR13462; PTHR13462; 1.
DR Pfam; PF04678; MCU; 1.
PE 2: Evidence at transcript level;
KW Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..5
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 6..293
FT /note="Calcium uniporter protein 4, mitochondrial"
FT /id="PRO_0000431373"
FT TRANSMEM 189..209
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 293 AA; 34260 MW; 8AF24707C9652990 CRC64;
MALRRAITKR LIDCYRSDVT QQHSFFRQLS PYNMKIHRQY MTSPNGPNLT DRIVGIRIES
VSPPRREETP VMGLSVSETK KLLRLYQMEK VKERLREIPK SSVSYWEFIQ ICCESCGNDE
QGSQMAKSLD HSGCVVVLGD IVFLHPHQIA KSMEAMIKQT SVLPNDPRKE ELVQLATTKK
SIDIEARRIV QAELYCGLGF LAVQTIGFMR LTFWELSWDV MEPICFFVTT IHFILGYIFF
LRTSTEPSFE GLFRQRFKTK QKKLMERHGF DFLRYNELNS LFTTFPCKFH YPV