MCU6_ARATH
ID MCU6_ARATH Reviewed; 292 AA.
AC F4I111; O80539;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Calcium uniporter protein 6, mitochondrial;
DE Flags: Precursor;
GN OrderedLocusNames=At1g09575 {ECO:0000312|Araport:AT1G09575};
GN ORFNames=F14J9.24 {ECO:0000312|EMBL:AAC33217.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND REVIEW.
RX PubMed=22200666; DOI=10.1093/jxb/err394;
RA Stael S., Wurzinger B., Mair A., Mehlmer N., Vothknecht U.C., Teige M.;
RT "Plant organellar calcium signalling: an emerging field.";
RL J. Exp. Bot. 63:1525-1542(2012).
CC -!- FUNCTION: Mitochondrial inner membrane calcium uniporter that mediates
CC calcium uptake into mitochondria. Mitochondrial calcium homeostasis
CC plays key roles in cellular physiology and regulates cell
CC bioenergetics, cytoplasmic calcium signals and activation of cell death
CC pathways. {ECO:0000250|UniProtKB:Q8NE86}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q8NE86}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q8NE86}.
CC -!- SIMILARITY: Belongs to the MCU (TC 1.A.77) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC33217.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AY056149; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC003970; AAC33217.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28464.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60638.1; -; Genomic_DNA.
DR EMBL; AY056149; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; E86229; E86229.
DR RefSeq; NP_001322910.1; NM_001331844.1.
DR RefSeq; NP_563846.1; NM_100829.2.
DR AlphaFoldDB; F4I111; -.
DR SMR; F4I111; -.
DR STRING; 3702.AT1G09575.1; -.
DR PaxDb; F4I111; -.
DR PRIDE; F4I111; -.
DR ProteomicsDB; 250833; -.
DR EnsemblPlants; AT1G09575.1; AT1G09575.1; AT1G09575.
DR EnsemblPlants; AT1G09575.2; AT1G09575.2; AT1G09575.
DR GeneID; 837484; -.
DR Gramene; AT1G09575.1; AT1G09575.1; AT1G09575.
DR Gramene; AT1G09575.2; AT1G09575.2; AT1G09575.
DR KEGG; ath:AT1G09575; -.
DR Araport; AT1G09575; -.
DR TAIR; locus:505006112; AT1G09575.
DR eggNOG; KOG2966; Eukaryota.
DR HOGENOM; CLU_066330_1_0_1; -.
DR InParanoid; F4I111; -.
DR OMA; MWRRLWW; -.
DR OrthoDB; 1076768at2759; -.
DR PRO; PR:F4I111; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4I111; baseline and differential.
DR Genevisible; F4I111; AT.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:1990246; C:uniplex complex; IBA:GO_Central.
DR GO; GO:0005262; F:calcium channel activity; IDA:TAIR.
DR GO; GO:0015292; F:uniporter activity; IBA:GO_Central.
DR GO; GO:0036444; P:calcium import into the mitochondrion; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IBA:GO_Central.
DR InterPro; IPR006769; MCU_C.
DR InterPro; IPR039055; MCU_fam.
DR PANTHER; PTHR13462; PTHR13462; 1.
DR Pfam; PF04678; MCU; 1.
PE 2: Evidence at transcript level;
KW Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..18
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 19..292
FT /note="Calcium uniporter protein 6, mitochondrial"
FT /id="PRO_0000431375"
FT TRANSMEM 172..192
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT CONFLICT 286
FT /note="A -> V (in Ref. 3; AY056149)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 33803 MW; 6BE7AD7FDACFDC94 CRC64;
MWSMGLIRRT AMSNAIRASS QRTWLGHGGL RSCVTVKTPS EDEEEKKKEI TIAEAKKLMR
LVNVEDMKKK LVGVADRDVV SYSTLLEASQ GMGIARSPDE AHVFARVLDD AGVVLIFRDK
VYLHPDKVVD LIRRAMPLDQ NPEEDQIKEE FNKLRIMKEE IDVLAHRQVR KILWCGLATS
MVQIGLFFRL TFWEFSWDVM EPITFFATAT GIIVGYAYFL MTSRDPTYQD FMKRLFLSRQ
RKLLKSHKFD CERFKELERL FKMTSSCHAA ASIRNRVGLE LDLEDALQSR RD
