ID   MCUR1_XENTR             Reviewed;         262 AA.
AC   Q0P4J6;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Mitochondrial calcium uniporter regulator 1 {ECO:0000250|UniProtKB:Q96AQ8};
DE            Short=MCU regulator 1 {ECO:0000250|UniProtKB:Q96AQ8};
DE   AltName: Full=Coiled-coil domain-containing protein 90A, mitochondrial {ECO:0000250|UniProtKB:Q96AQ8};
GN   Name=mcur1 {ECO:0000250|UniProtKB:Q96AQ8};
GN   Synonyms=ccdc90a {ECO:0000250|UniProtKB:Q96AQ8};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Skeletal muscle;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key regulator of mitochondrial calcium uniporter (mcu)
CC       required for calcium entry into mitochondrion.
CC       {ECO:0000250|UniProtKB:Q96AQ8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q96AQ8}; Single-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q96AQ8}.
CC   -!- SIMILARITY: Belongs to the CCDC90 family. {ECO:0000305}.
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DR   EMBL; BC122047; AAI22048.1; -; mRNA.
DR   RefSeq; NP_001072845.1; NM_001079377.1.
DR   AlphaFoldDB; Q0P4J6; -.
DR   SMR; Q0P4J6; -.
DR   STRING; 8364.ENSXETP00000004851; -.
DR   PaxDb; Q0P4J6; -.
DR   DNASU; 780306; -.
DR   Ensembl; ENSXETT00000004851; ENSXETP00000004851; ENSXETG00000002272.
DR   GeneID; 780306; -.
DR   KEGG; xtr:780306; -.
DR   CTD; 63933; -.
DR   Xenbase; XB-GENE-995495; mcur1.
DR   eggNOG; KOG3156; Eukaryota.
DR   HOGENOM; CLU_063283_1_0_1; -.
DR   InParanoid; Q0P4J6; -.
DR   OMA; TEIMEMT; -.
DR   OrthoDB; 1252164at2759; -.
DR   TreeFam; TF331442; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000002272; Expressed in skeletal muscle tissue and 12 other tissues.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0036444; P:calcium import into the mitochondrion; ISS:UniProtKB.
DR   GO; GO:0070509; P:calcium ion import; ISS:UniProtKB.
DR   GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; ISS:UniProtKB.
DR   InterPro; IPR024461; CCDC90-like.
DR   InterPro; IPR012439; MCUR1.
DR   PANTHER; PTHR14360; PTHR14360; 1.
DR   PANTHER; PTHR14360:SF11; PTHR14360:SF11; 1.
DR   Pfam; PF07798; DUF1640; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium transport; Coiled coil; Ion transport; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..262
FT                   /note="Mitochondrial calcium uniporter regulator 1"
FT                   /id="PRO_0000295694"
FT   TRANSMEM        239..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          138..175
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   262 AA;  30024 MW;  E7DAE32906A7DBAB CRC64;
     MSRLQLRFLL RRALSGSGCP RYSMPGSGCP GCFLPRVTCF RDFNIITSTM QYNLDKRNIY
     TSVGKHYFFD THAVVQLLEA NGFSAEQSEI VVSALVKILN VNMNLIHKDM VTKEQQEISL
     QQVMSLIASV KKDMIILEKS EFSALRTQNE KVKIELQQLK KQLNDSIVKV RASNKLDFNL
     EKSRVKEMHA DNERKLLELR TSIVELHSQQ DRGLTQTKRK IDTEVSGVKT MQESHKLDTI
     KYLAGSVFTC LTIALGFYRL WI