MD12L_HUMAN
ID MD12L_HUMAN Reviewed; 2145 AA.
AC Q86YW9; Q96PC7; Q96PC8; Q9H9M5; Q9HCD7; Q9UI69;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 12-like protein;
DE AltName: Full=Mediator complex subunit 12-like protein;
DE AltName: Full=Thyroid hormone receptor-associated-like protein;
DE AltName: Full=Trinucleotide repeat-containing gene 11 protein-like;
GN Name=MED12L; Synonyms=KIAA1635, TNRC11L, TRALP, TRALPUSH; ORFNames=PRO0314;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
RX PubMed=11524702; DOI=10.1086/323610;
RA Joensuu T., Haemaelaeinen R., Yuan B., Johnson C., Tegelberg S.,
RA Gasparini P., Zelante L., Pirvola U., Pakarinen L., Lehesjoki A.-E.,
RA de la Chapelle A., Sankila E.-M.;
RT "Mutations in a novel gene with transmembrane domains underlie Usher
RT syndrome type 3.";
RL Am. J. Hum. Genet. 69:673-684(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Adato A., Avidan N., Ben-Asher E., Khen M., Man O., Beckmann J.S.,
RA Bonne-Tamir B., Lancet D.;
RT "Tralpush, a novel transcription-related gene, that spans the entire USHER
RT syndrome type-3 linkage interval encloses five G-protein-coupled receptor
RT genes nested within its introns.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 711-2145 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:273-281(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 808-1763 (ISOFORM 4).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1175-1608 (ISOFORMS 1/4).
RC TISSUE=Fetal liver;
RX PubMed=11483580; DOI=10.1101/gr.175501;
RA Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C., Zhai Y.,
RA Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C., He F.;
RT "Gene expression profiling in human fetal liver and identification of
RT tissue- and developmental-stage-specific genes through compiled expression
RT profiles and efficient cloning of full-length cDNAs.";
RL Genome Res. 11:1392-1403(2001).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-462, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP INVOLVEMENT IN NIZIDS, AND VARIANT NIZIDS 1998-GLN--PHE-2145 DEL.
RX PubMed=31155615; DOI=10.1038/s41436-019-0557-3;
RA Nizon M., Laugel V., Flanigan K.M., Pastore M., Waldrop M.A.,
RA Rosenfeld J.A., Marom R., Xiao R., Gerard A., Pichon O., Le Caignec C.,
RA Gerard M., Dieterich K., Truitt Cho M., McWalter K., Hiatt S.,
RA Thompson M.L., Bezieau S., Wadley A., Wierenga K.J., Egly J.M., Isidor B.;
RT "Variants in MED12L, encoding a subunit of the mediator kinase module, are
RT responsible for intellectual disability associated with transcriptional
RT defect.";
RL Genet. Med. 21:2713-2722(2019).
CC -!- FUNCTION: May be a component of the Mediator complex, a coactivator
CC involved in the regulated transcription of nearly all RNA polymerase
CC II-dependent genes. Mediator functions as a bridge to convey
CC information from gene-specific regulatory proteins to the basal RNA
CC polymerase II transcription machinery. Mediator is recruited to
CC promoters by direct interactions with regulatory proteins and serves as
CC a scaffold for the assembly of a functional preinitiation complex with
CC RNA polymerase II and the general transcription factors (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: May be a component of the Mediator complex, which is known to
CC be composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12,
CC MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21,
CC MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC,
CC CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a
CC distinct module termed the CDK8 module. Mediator containing the CDK8
CC module is less active than Mediator lacking this module in supporting
CC transcriptional activation. Individual preparations of the Mediator
CC complex lacking one or more distinct subunits have been variously
CC termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q86YW9; P61024: CKS1B; NbExp=3; IntAct=EBI-3957138, EBI-456371;
CC Q86YW9; P45984: MAPK9; NbExp=3; IntAct=EBI-3957138, EBI-713568;
CC Q86YW9; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-3957138, EBI-10699187;
CC Q86YW9; Q08117-2: TLE5; NbExp=3; IntAct=EBI-3957138, EBI-11741437;
CC Q86YW9; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-3957138, EBI-9090990;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q86YW9-1; Sequence=Displayed;
CC Name=2; Synonyms=NOPAR;
CC IsoId=Q86YW9-2; Sequence=VSP_029995, VSP_029996;
CC Name=3; Synonyms=NOPAR2;
CC IsoId=Q86YW9-3; Sequence=VSP_029994, VSP_029995, VSP_029996;
CC Name=4;
CC IsoId=Q86YW9-4; Sequence=VSP_029997;
CC -!- DISEASE: Nizon-Isidor syndrome (NIZIDS) [MIM:618872]: An autosomal
CC dominant neurodevelopmental disorder characterized by intellectual
CC disability, global developmental delay, speech impairment, and
CC behavioral abnormalities including autism spectrum disorder and
CC aggressive behavior. Other features include a thin corpus callosum, and
CC mild facial dysmorphism. Disease onset is in infancy or early
CC childhood. {ECO:0000269|PubMed:31155615}. Note=The disease is caused by
CC variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 12 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24035.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part and potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAB14198.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF388364; AAL09579.1; -; mRNA.
DR EMBL; AF388365; AAL09580.1; -; mRNA.
DR EMBL; AF399708; AAO38813.1; -; mRNA.
DR EMBL; CH471052; EAW78800.1; -; Genomic_DNA.
DR EMBL; AB046855; BAB13461.1; -; mRNA.
DR EMBL; AK022714; BAB14198.1; ALT_INIT; mRNA.
DR EMBL; AF090917; AAF24035.1; ALT_SEQ; mRNA.
DR CCDS; CCDS33876.1; -. [Q86YW9-1]
DR RefSeq; NP_443728.3; NM_053002.5. [Q86YW9-1]
DR RefSeq; XP_011510692.1; XM_011512390.2. [Q86YW9-1]
DR AlphaFoldDB; Q86YW9; -.
DR BioGRID; 125538; 45.
DR IntAct; Q86YW9; 21.
DR MINT; Q86YW9; -.
DR STRING; 9606.ENSP00000417235; -.
DR iPTMnet; Q86YW9; -.
DR PhosphoSitePlus; Q86YW9; -.
DR BioMuta; MED12L; -.
DR DMDM; 166232934; -.
DR EPD; Q86YW9; -.
DR jPOST; Q86YW9; -.
DR MassIVE; Q86YW9; -.
DR MaxQB; Q86YW9; -.
DR PaxDb; Q86YW9; -.
DR PeptideAtlas; Q86YW9; -.
DR PRIDE; Q86YW9; -.
DR ProteomicsDB; 70486; -. [Q86YW9-1]
DR ProteomicsDB; 70487; -. [Q86YW9-2]
DR ProteomicsDB; 70488; -. [Q86YW9-3]
DR ProteomicsDB; 70489; -. [Q86YW9-4]
DR Antibodypedia; 46744; 25 antibodies from 14 providers.
DR DNASU; 116931; -.
DR Ensembl; ENST00000309237.8; ENSP00000310760.4; ENSG00000144893.13. [Q86YW9-3]
DR Ensembl; ENST00000422248.6; ENSP00000403308.2; ENSG00000144893.13. [Q86YW9-2]
DR Ensembl; ENST00000474524.5; ENSP00000417235.1; ENSG00000144893.13. [Q86YW9-1]
DR GeneID; 116931; -.
DR KEGG; hsa:116931; -.
DR UCSC; uc003eyn.3; human. [Q86YW9-1]
DR CTD; 116931; -.
DR DisGeNET; 116931; -.
DR GeneCards; MED12L; -.
DR HGNC; HGNC:16050; MED12L.
DR HPA; ENSG00000144893; Tissue enhanced (brain, choroid plexus).
DR MalaCards; MED12L; -.
DR MIM; 611318; gene.
DR MIM; 618872; phenotype.
DR neXtProt; NX_Q86YW9; -.
DR OpenTargets; ENSG00000144893; -.
DR Orphanet; 178469; Autosomal dominant non-syndromic intellectual disability.
DR PharmGKB; PA134884590; -.
DR VEuPathDB; HostDB:ENSG00000144893; -.
DR eggNOG; KOG3598; Eukaryota.
DR GeneTree; ENSGT00440000037505; -.
DR HOGENOM; CLU_383529_0_0_1; -.
DR InParanoid; Q86YW9; -.
DR OMA; HSMILQK; -.
DR OrthoDB; 15873at2759; -.
DR PhylomeDB; Q86YW9; -.
DR TreeFam; TF324178; -.
DR PathwayCommons; Q86YW9; -.
DR SignaLink; Q86YW9; -.
DR BioGRID-ORCS; 116931; 11 hits in 1072 CRISPR screens.
DR ChiTaRS; MED12L; human.
DR GenomeRNAi; 116931; -.
DR Pharos; Q86YW9; Tdark.
DR PRO; PR:Q86YW9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q86YW9; protein.
DR Bgee; ENSG00000144893; Expressed in monocyte and 102 other tissues.
DR ExpressionAtlas; Q86YW9; baseline and differential.
DR Genevisible; Q86YW9; HS.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR019035; Mediator_Med12.
DR InterPro; IPR021989; Mediator_Med12_catenin-bd.
DR InterPro; IPR021990; Mediator_Med12_LCEWAV.
DR Pfam; PF09497; Med12; 1.
DR Pfam; PF12145; Med12-LCEWAV; 1.
DR Pfam; PF12144; Med12-PQL; 1.
DR SMART; SM01281; Med12; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Autism spectrum disorder; Disease variant;
KW Intellectual disability; Nucleus; Phosphoprotein; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..2145
FT /note="Mediator of RNA polymerase II transcription subunit
FT 12-like protein"
FT /id="PRO_0000313053"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1436..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1721..1802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2029..2145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1436..1457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1749..1780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1781..1802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2052..2069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2079..2145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 462
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VAR_SEQ 656
FT /note="E -> EEQSIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFP (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:11524702"
FT /id="VSP_029994"
FT VAR_SEQ 716..721
FT /note="DESSSH -> VSHCFS (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:11524702"
FT /id="VSP_029995"
FT VAR_SEQ 722..2145
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:11524702"
FT /id="VSP_029996"
FT VAR_SEQ 951
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029997"
FT VARIANT 401
FT /note="Q -> P (in dbSNP:rs17290219)"
FT /id="VAR_037647"
FT VARIANT 464
FT /note="E -> K (in dbSNP:rs3108728)"
FT /id="VAR_037648"
FT VARIANT 903
FT /note="Q -> H (in dbSNP:rs2131100)"
FT /id="VAR_037649"
FT VARIANT 1210
FT /note="R -> Q (in dbSNP:rs3732765)"
FT /id="VAR_037650"
FT VARIANT 1698
FT /note="R -> Q (in dbSNP:rs2276761)"
FT /id="VAR_037651"
FT VARIANT 1998..2145
FT /note="Missing (in NIZIDS)"
FT /evidence="ECO:0000269|PubMed:31155615"
FT /id="VAR_084189"
FT CONFLICT 1088
FT /note="I -> T (in Ref. 5; BAB14198)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2145 AA; 240120 MW; 578F84E1C76004C9 CRC64;
MAAFGLLSYE QRPLKRPRLG PPDVYPQDPK QKEDELTAVN VKQGFNNQPA FTGDEHGSAR
NIVINPSKIG AYFSSILAEK LKLNTFQDTG KKKPQVNAKD NYWLVTARSQ SAIHSWFSDL
AGNKPLSILA KKVPILSKKE DVFAYLAKYS VPMVRATWLI KMTCAYYSAI SEAKIKKRQA
PDPNLEWTQI STRYLREQLA KISDFYHMAS STGDGPVPVP PEVEQAMKQW EYNEKLAFHM
FQEGMLEKHE YLTWILDVLE KIRPMDDDLL KLLLPLMLQY SDEFVQSAYL SRRLAYFCAR
RLSLLLSDSP NLLAAHSPHM MIGPNNSSIG APSPGPPGPG MSPVQLAFSD FLSCAQHGPL
VYGLSCMLQT VTLCCPSALV WNYSTNENKS ANPGSPLDLL QVAPSSLPMP GGNTAFNQQV
RARIYEVEQQ IKQRGRAVEV RWSFDKCQES TAGVTISRVL HTLEVLDRHC FDRTDSSNSM
ETLYHKIFWA NQNKDNQEVA PNDEAVVTLL CEWAVSCKRS GKHRAMAVAK LLEKRQAEIE
AERCGESEVL DEKESISSSS LAGSSLPVFQ NVLLRFLDTQ APSLSDPNSE CEKVEFVNLV
LLFCEFIRHD VFSHDAYMCT LISRGDLSVT ASTRPRSPVG ENADEHYSKD HDVKMEIFSP
MPGESCENAN TSLGRRMSVN CEKLVKREKP RELIFPSNYD LLRHLQYATH FPIPLDESSS
HECNQRTILL YGVGKERDEA RHQLKKITKD ILKILNKKST TETGVGDEGQ KARKNKQETF
PTLETVFTKL QLLSYFDQHQ VTSQISNNVL EQITSFASGT SYHLPLAHHI QLIFDLMEPA
LNINGLIDFA IQLLNELSVV EAELLLKSSS LAGSYTTGLC VCIVAVLRRY HSCLILNPDQ
TAQVFEGLCG VVKHVVNPSE CSSPERCILA YLYDLYVSCS HLRSKFGDLF SSACSKVKQT
IYNNVMPANS NLRWDPDFMM DFIENPSARS INYSMLGKIL SDNAANRYSF VCNTLMNVCM
GHQDAGRIND IANFSSELTA CCTVLSSEWL GVLKALCCSS NHVWGFNDVL CTVDVSDLSF
HDSLATFIAI LIARQCFSLE DVVQHVALPS LLAAACGDAD AEPGARMTCR LLLHLFRAPQ
ACFLPQATGK PFPGIRSSCD RHLLAAAHNS IEVGAVFAVL KAIMMLGDAK IGNNSVSSLK
NDDFTMRGLR CDGNADDIWT ASQNPKSCGK SISIETANLR EYARYVLRTI CQQEWVGEHC
LKEPERLCTD KELILDPVLS NMQAQKLLQL ICYPHGIKEC TEGDNLQRQH IKRILQNLEQ
WTLRQSWLEL QLMIKQCLKD PGSGSVAEMN NLLDNIAKAT IEVFQQSADL NNSSNSGMSL
FNPNSIGSAD TSSTRQNGIK TFLSSSERRG VWLVAPLIAR LPTSVQGRVL KAAGEELEKG
QHLGSSSKKE RDRQKQKSMS LLSQQPFLSL VLTCLKGQDE QREGLLTSLQ NQVNQILSNW
REERYQDDIK ARQMMHEALQ LRLNLVGGMF DTVQRSTQWT TDWALLLLQI ITSGTVDMHT
NNELFTTVLD MLGVLINGTL ASDLSNASPG GSEENKRAYM NLVKKLKKEL GDKRSESIDK
VRQLLPLPKQ TCDVITCEPM GSLIDTKGNK IAGFDSIDKK QGLQVSTKQK VSPWDLFEGQ
KNPAPLSWAW FGTVRVDRRV IKYEEQHHLL LYHTHPMPKP RSYYLQPLPL PPEEEEEEPT
SPVSQEPERK SAELSDQGKT TTDEEKKTKG RKRKTKSSSR VDEYPQSNIY RVPPNYSPIS
SQMMHHPQST LWGYNLVGQP QQPGFFLQNQ SLTPGGSRLD PAGSFVPTNT KQALSNMLQR
RSGAMMQPPS LHAITSQQQL IQMKLLQQQQ QQRLLRQAQT RPFQQGQPGD QAALFAAQAR
PSPQLPQYPG LQQAQTMPQG YTMYGTQMPL QQTSQQQAGS VVLSPSYNSR AYPAAHSNPV
LMERLRQIQQ QPSGYVQQQA SPYLQPLTGS QRLNHQALQQ SPLVGGGIDA VLTSAHPNLP
SVPLPQDPMR PRQPQVRQQQ RLLQMQQPQQ PQPQQPPQPQ QSSQSQSQTL GLQAMQPQQP
LFPRQGLQQT QQQQQTAALV RQLQKQLSSN QPQQGVTPYG HPSHF
