MD13L_DANRE
ID MD13L_DANRE Reviewed; 2102 AA.
AC A2VCZ5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13-like;
DE AltName: Full=Thyroid hormone receptor-associated protein complex 240 kDa component-like protein;
GN ORFNames=zgc:153454;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated gene transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000305}.
CC -!- CAUTION: This sequence is encoded by a gene on chromosome 15 and is
CC unlikely to be the med13 ortholog because it shows similarity but not
CC synteny with human MED13. The chromosome 10 med13 gene identified by
CC PubMed:17208216 is distinct from this entry. {ECO:0000305}.
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DR EMBL; BC129032; AAI29033.1; -; mRNA.
DR RefSeq; NP_001077307.1; NM_001083838.1.
DR AlphaFoldDB; A2VCZ5; -.
DR STRING; 7955.ENSDARP00000126727; -.
DR PaxDb; A2VCZ5; -.
DR PeptideAtlas; A2VCZ5; -.
DR GeneID; 564707; -.
DR KEGG; dre:564707; -.
DR CTD; 564707; -.
DR ZFIN; ZDB-GENE-030131-3529; med13b.
DR eggNOG; KOG3600; Eukaryota.
DR InParanoid; A2VCZ5; -.
DR OrthoDB; 177884at2759; -.
DR PhylomeDB; A2VCZ5; -.
DR PRO; PR:A2VCZ5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0001755; P:neural crest cell migration; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 2: Evidence at transcript level;
KW Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..2102
FT /note="Mediator of RNA polymerase II transcription subunit
FT 13-like"
FT /id="PRO_0000314241"
FT REGION 304..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1451..1574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1948..1983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1165..1169
FT /note="LXXLL motif 1"
FT MOTIF 1254..1258
FT /note="LXXLL motif 2"
FT COMPBIAS 315..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..710
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..998
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1451..1556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1968..1982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2102 AA; 230992 MW; EB09861E48DCFDE7 CRC64;
MSSCFVPNGA SLEDCHSNLF CLADLTGIKW KCFVWQGPTS SPILFPVTEE DPILCSFSRC
LKADVLSVWR RHQTPGRREL WIFWWGDDPN FAELVHHDLS CNEDGSWESG LTYECRTLLF
KAIHNLLERC LMNRSFVRIG KWFVKPYEKD EKPINKSEHL SCSFTFFVHG DSNVCTSVEI
NQHQPVYLLS EEHLTLAQQS SSSVQVILSP YGLSGTLTGQ SFKLSDPPTQ KLIEEWKQFY
PIGPNTKEVT DDKMDDLDWE DDSLAAVEVV VAGVRMVYPA SLVLVAQSDI PLVATVSSSS
SSGSYAGAPH NQLVHGDTGI SSVTLTPPTS PEEAQAVSQP AQKWVKLSAM SGVFSVDSSS
HHGGKIPRRL ASQMVERVWQ ECNINRAQNK RKFSTMSNGV CEEETDKASV WDFVESSQRS
QCSCSRLKNQ KQRACSTPGH PPSAGQPPQP STKHKMAEKL EKGDKQQKRP LTPFHHRSSL
CEEQPSLEQG ESVHRLCLQG HEDSRYPSLH HADVTSSKTP MLHSSADEMA GSPQPPPLSP
HPCERMEEPA DGMKSSSSPL HQHFYPPSSE PCLEPQKPPD ESTLDPLPLP CPPPYPETLE
ATIYVGSAIN PNEDTTHNPW KYFRVPGGRN SDFHTPHLPV VAHFEDGNRT GGQDGIVSIT
EMMSSSKRPL KVSEELVKMY EHKKNQYLSS AVCDEDPEQE SDPYAFEEGD EEFNFSDKDK
KSGPEREAGK KAKREDGSSS SDDAQGSGGS KPLPTTSLIH ETDLVVSIND LDNLFNSDED
DLTQPGSRRA AGGAEEKFGG KEPKPAAPDP LPCCADLHQM FPTPPSLDQG YSPINMGNTE
SAAGLSLLDG AMSGNFKMEV EEGFCSPKPS EIKDFSYVFK PESCQALIGC SLYAPLKTLP
SQCLLPVKLP EECVYRPSWT VGKLGMLQPM AAMTFLNKDS NIPSVGSVVE QEQSCTPQTH
NTFMSNSAPP SNSGAGILPS PATPRISAPT PRTPRTPRTP RGPASVQGSL KYENSDLNSP
ASTPSTCRPL SSVEPATVPS IPEAHSLYVT LILSESVMNL FKDCNFDSCC ICVCNMNITG
ADVGIYISDP NMDSQYSSMD PCSCGFSAVM NRRYGNGAGL FLEDELDIMG RGSDAAREIE
KHFEAVRAAS LKRGTVLEEQ VPDDLMLLLQ DLCTNPFSPI IRPDLLGTVI KSPIRLEERD
YYSDCYMALE HGRQFMDNMS GGKVDETLVK SSSLHHWAKR NAFDMSMLFS QDVLRMLLSL
QPVLQDTIQK KRSVRSWGVQ GPLTWQQFHK MAGRGSYGTD ESPEPLPIPT LLVGYEYDYV
VLSPFALPYW EKLLLDPYSS QRDVGYMVVC PDNEALLNGA KTFFRDLTAV YESCRLGQHR
PIAKSHADGI VTVSDAGSKA LTDQTLIDWL PKTINSSSSS EALNKLKLYA HVCRHDLASC
LASQSLDGSL LTQRNPASSS QTSSSSSPVT TAQNVTPTTN SNSNTNTNTT PTSTSTSSSS
SSCPQGVGNM PSSKPNTIPP FGAQGLQSSQ QSGGQSAGTL GDATSATSQP QVPSEPAEST
MEREKVGVPT DGDSHAVTYP PAIVIYIVNP FSYEENCQGS SSSVWTIALL RCYLEMLQLL
PPHIRNAVYV QIIPSQYLLQ PVWSEERHIY AQHLKSLAFS VYTQCRRRLP TSTNVKTLTG
FGPGLAIDTA LQSKERPQCL HLYAPPFVLA PVKDKQTELG ETFGEAAQKY NVLFVAYCLS
HDQRWLLASC TDQYGELLET CVISIDVPNR ARRKKGSARR QGLQKLWEWC LDLVQMTSLP
WRIVIGRLGR IGHGELRDWS ILLSRRNLQS LGRRLKEMCR MCGISAADSP SILSTCLVAM
EPQASFVIMP DSVSTGSVFG RSTTLNMQTS QLNTPQDTSC THILVFPTSA GLQAFSDVTD
GMGGMDGILD LFAENDLVDP DLINIIPNSP TTSPVHSPGS HYHHGGDGSK GQGTDRMESH
DESPNILQQP MALGYFVSTA KAGPLPDWFW SSCPQAKNQC PLFLKASLHL NVSSVQSDEL
LHSKHSHPLD SSHTSDVLRF VLEQYNALSW LTCDPATQDR RSCLPVHFVV LNQMYNFIMN
ML
