ID   MD15B_ARATH             Reviewed;         293 AA.
AC   F4I169; Q9LMQ7;
DT   11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Probable mediator of RNA polymerase II transcription subunit 15b;
GN   Name=MED15B; Synonyms=MED15_1; OrderedLocusNames=At1g15770;
GN   ORFNames=F7H2.11;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   IDENTIFICATION, AND NOMENCLATURE.
RX   PubMed=22021418; DOI=10.1104/pp.111.188300;
RA   Mathur S., Vyas S., Kapoor S., Tyagi A.K.;
RT   "The Mediator complex in plants: structure, phylogeny, and expression
RT   profiling of representative genes in a dicot (Arabidopsis) and a monocot
RT   (rice) during reproduction and abiotic stress.";
RL   Plant Physiol. 157:1609-1627(2011).
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. The Mediator complex, having a compact
CC       conformation in its free form, is recruited to promoters by direct
CC       interactions with regulatory proteins and serves for the assembly of a
CC       functional preinitiation complex with RNA polymerase II and the general
CC       transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the plant Mediator complex subunit 15 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF82147.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC034256; AAF82147.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE29362.1; -; Genomic_DNA.
DR   PIR; A86292; A86292.
DR   RefSeq; NP_173029.2; NM_101445.3.
DR   AlphaFoldDB; F4I169; -.
DR   BioGRID; 23386; 4.
DR   STRING; 3702.AT1G15770.1; -.
DR   PaxDb; F4I169; -.
DR   PRIDE; F4I169; -.
DR   EnsemblPlants; AT1G15770.1; AT1G15770.1; AT1G15770.
DR   GeneID; 838146; -.
DR   Gramene; AT1G15770.1; AT1G15770.1; AT1G15770.
DR   KEGG; ath:AT1G15770; -.
DR   Araport; AT1G15770; -.
DR   TAIR; locus:2036139; AT1G15770.
DR   eggNOG; ENOG502QQV3; Eukaryota.
DR   HOGENOM; CLU_951061_0_0_1; -.
DR   OMA; LQERNFM; -.
DR   OrthoDB; 250561at2759; -.
DR   PRO; PR:F4I169; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; F4I169; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031490; F:chromatin DNA binding; IBA:GO_Central.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR   InterPro; IPR044661; MED15a/b/c-like.
DR   PANTHER; PTHR33137; PTHR33137; 2.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..293
FT                   /note="Probable mediator of RNA polymerase II transcription
FT                   subunit 15b"
FT                   /id="PRO_0000418349"
SQ   SEQUENCE   293 AA;  32658 MW;  0729F4D50917C8A6 CRC64;
     MIILLFFVDQ IHQRDLNEIY QRVAAKLQQE DSLSHQKQRS DQFEKLKRGK TVLEGMLRFL
     SLSKSNIKPD LKDSMDYRKN NIMNFLNMQS LRKTVQKLQL TKSEIQPMQQ PLSQTVQDQS
     HDDQTTLQMQ SMSMQGAGSR VQQIRQGVLQ SLEIGTPGIS ASPLLPELTS PDGNIINPLT
     STCGKSSATE LPIERLIRAM KSISPQALSS AVCDIRSVVS MVDRIAGSVP GKGSRASFGV
     DLVAMTKCHL QERNFMTQDG DHEKEASDNP NAIKCCFIGR KALVIATSIL LVW