ID   MD19A_DANRE             Reviewed;         242 AA.
AC   Q08C81;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 19-A;
DE   AltName: Full=Mediator complex subunit 19-A;
GN   Name=med19a; ORFNames=zgc:153400;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larval eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC       {ECO:0000305}.
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DR   EMBL; BC124344; AAI24345.1; -; mRNA.
DR   RefSeq; NP_001070059.1; NM_001076591.1.
DR   AlphaFoldDB; Q08C81; -.
DR   SMR; Q08C81; -.
DR   STRING; 7955.ENSDARP00000054409; -.
DR   PaxDb; Q08C81; -.
DR   Ensembl; ENSDART00000054410; ENSDARP00000054409; ENSDARG00000037392.
DR   Ensembl; ENSDART00000191087; ENSDARP00000149969; ENSDARG00000114246.
DR   GeneID; 767651; -.
DR   KEGG; dre:767651; -.
DR   CTD; 767651; -.
DR   ZFIN; ZDB-GENE-060929-232; med19a.
DR   eggNOG; KOG4043; Eukaryota.
DR   GeneTree; ENSGT00390000001774; -.
DR   HOGENOM; CLU_098332_0_0_1; -.
DR   InParanoid; Q08C81; -.
DR   OMA; KQKRHDD; -.
DR   OrthoDB; 1484317at2759; -.
DR   PhylomeDB; Q08C81; -.
DR   TreeFam; TF317417; -.
DR   PRO; PR:Q08C81; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 14.
DR   Bgee; ENSDARG00000037392; Expressed in gastrula and 22 other tissues.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019403; Mediator_Med19_met.
DR   PANTHER; PTHR22536; PTHR22536; 1.
DR   Pfam; PF10278; Med19; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..242
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   19-A"
FT                   /id="PRO_0000304769"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          171..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..212
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   242 AA;  26818 MW;  B33010CFEACDFC71 CRC64;
     MTEIFSTLFG QNDAQPPSGP AALGFAPGKP PPSMPPNQAP IAAQMPGQLG DDGPLLRKPG
     AMNEPFYLLR ELPVGNDLTG NTNLITHYNL EHAYNKFCGK KVKEKLSNFL PELPGMIDCP
     GVQDGSSLRS LIEKPPVCGN SFSPLTGALL TGFRLHTGPL PEQYRLMHIQ PPKKKSKHKH
     RHHHPQDPLP LETRTDPTKK KKKKDNEPER RKKKKDKKKK KNRHSPDHPG VTGSQPNSNS
     LR