ID   MD19B_DANRE             Reviewed;         240 AA.
AC   Q6DRL8; Q568S3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 19-B;
DE   AltName: Full=Mediator complex subunit 19-B;
GN   Name=med19b; Synonyms=med19; ORFNames=zgc:110121;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA   Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA   Hopkins N.;
RT   "Identification of 315 genes essential for early zebrafish development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 19 family.
CC       {ECO:0000305}.
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DR   EMBL; AY648741; AAT68059.1; -; mRNA.
DR   EMBL; BC092743; AAH92743.1; -; mRNA.
DR   RefSeq; NP_001003416.2; NM_001003416.2.
DR   AlphaFoldDB; Q6DRL8; -.
DR   SMR; Q6DRL8; -.
DR   STRING; 7955.ENSDARP00000116331; -.
DR   Ensembl; ENSDART00000003022; ENSDARP00000016407; ENSDARG00000009472.
DR   GeneID; 445021; -.
DR   KEGG; dre:445021; -.
DR   CTD; 445021; -.
DR   ZFIN; ZDB-GENE-040727-4; med19b.
DR   eggNOG; KOG4043; Eukaryota.
DR   GeneTree; ENSGT00390000001774; -.
DR   HOGENOM; CLU_098332_0_0_1; -.
DR   InParanoid; Q6DRL8; -.
DR   OrthoDB; 1484317at2759; -.
DR   PhylomeDB; Q6DRL8; -.
DR   PRO; PR:Q6DRL8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000009472; Expressed in mature ovarian follicle and 21 other tissues.
DR   ExpressionAtlas; Q6DRL8; baseline and differential.
DR   GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR019403; Mediator_Med19_met.
DR   PANTHER; PTHR22536; PTHR22536; 1.
DR   Pfam; PF10278; Med19; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..240
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   19-B"
FT                   /id="PRO_0000304768"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          168..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..223
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        151
FT                   /note="L -> S (in Ref. 2; AAH92743)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   240 AA;  27005 MW;  834D452DAB26F574 CRC64;
     MTEIFSSLYG QPDSQGPAGP SALGFGSGKP QVPQNMGPMC FPHQMMEEGA PVRKPAAMNE
     PFYLLRELPM ENELTGHTNL ITHYNLEHAY NKFCGKKVKE KLSNFLPELP GMIDSPGIQD
     NSSLRSLIEK PPVCNNSFSP LTGAMLTGFR LHTGPLPEQY RLMHIQPPKK KNKHKHKHHR
     PQDPLPPETP SDSDHKKKKK KKDDDPDRKK KKKDKKKKKN RHSPDHPGMT GAQPSTSSLR