ID   MD2L2_DICDI             Reviewed;         332 AA.
AC   Q54S00;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Mitotic spindle assembly checkpoint protein MAD2B;
DE   AltName: Full=Mitotic arrest deficient 2-like protein 2;
DE            Short=MAD2-like protein 2;
GN   Name=mad2l2; Synonyms=mad2b; ORFNames=DDB_G0282747;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Adapter protein able to interact with different proteins and
CC       involved in different biological processes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAD2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000047; EAL66233.1; -; Genomic_DNA.
DR   RefSeq; XP_640239.1; XM_635147.1.
DR   AlphaFoldDB; Q54S00; -.
DR   SMR; Q54S00; -.
DR   STRING; 44689.DDB0305034; -.
DR   PaxDb; Q54S00; -.
DR   EnsemblProtists; EAL66233; EAL66233; DDB_G0282747.
DR   GeneID; 8623778; -.
DR   KEGG; ddi:DDB_G0282747; -.
DR   dictyBase; DDB_G0282747; -.
DR   eggNOG; KOG3186; Eukaryota.
DR   HOGENOM; CLU_837900_0_0_1; -.
DR   InParanoid; Q54S00; -.
DR   OMA; VWISTTE; -.
DR   Reactome; R-DDI-110312; Translesion synthesis by REV1.
DR   PRO; PR:Q54S00; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016035; C:zeta DNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.900.10; -; 1.
DR   InterPro; IPR003511; HORMA_dom.
DR   InterPro; IPR036570; HORMA_dom_sf.
DR   InterPro; IPR045091; Mad2-like.
DR   PANTHER; PTHR11842; PTHR11842; 1.
DR   Pfam; PF02301; HORMA; 1.
DR   SUPFAM; SSF56019; SSF56019; 1.
DR   PROSITE; PS50815; HORMA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..332
FT                   /note="Mitotic spindle assembly checkpoint protein MAD2B"
FT                   /id="PRO_0000328298"
FT   DOMAIN          4..332
FT                   /note="HORMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT   REGION          181..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          225..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..244
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   332 AA;  37875 MW;  4BC4DBC7274A4A98 CRC64;
     MLDEHFCDCI GEFLETSFHC ILYIRGVYPS CLFSKSIKYD IPVPISRSDL LTRYISNSID
     SLKPHFLKDT IEKISLTILN KYDKPIEKFI FEISSLNNTT NNKNKNNNNN NNNSDDDETF
     NYYINIQKQN YTSNNNNNNN NNINNNNNKP NLLQLEASFK AYIIKILMTT DSFYSEQNFY
     KTQQSSSSSS SLKTSGGGDG NGFISNSDGV IHFNEIDNET YQQIKSNQKN KKEDNDDNNN
     GDKDLKFTIH VHTKPTTSNI GLNTNLSNVI LNINPLESPR RTNTTINQIT PVWISTTEKD
     SEIENSYIIP LNSNITDGKT TIRTFTEQSI TK