ID   MD31A_XENLA             Reviewed;         128 AA.
AC   Q4QR03;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 31-A;
DE   AltName: Full=Mediator complex subunit 31-A;
DE   AltName: Full=Mediator complex subunit soh1-A;
GN   Name=med31-a; Synonyms=soh1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 31 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH97742.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC097742; AAH97742.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001089501.2; NM_001096032.1.
DR   AlphaFoldDB; Q4QR03; -.
DR   SMR; Q4QR03; -.
DR   DNASU; 734553; -.
DR   GeneID; 734553; -.
DR   KEGG; xla:734553; -.
DR   CTD; 734553; -.
DR   Xenbase; XB-GENE-6255891; med31.L.
DR   OrthoDB; 1480492at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 734553; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   Gene3D; 1.10.10.1340; -; 1.
DR   InterPro; IPR038089; Med31_sf.
DR   InterPro; IPR008831; Mediator_Med31.
DR   PANTHER; PTHR13186; PTHR13186; 1.
DR   Pfam; PF05669; Med31; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..128
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   31-A"
FT                   /id="PRO_0000305709"
SQ   SEQUENCE   128 AA;  15719 MW;  AA252FAFC0208F93 CRC64;
     MAATMETDEQ QRIRFQLELE FVQCLANPNY LNFLAQRGYF KDKPFVNYMK YLLYWKEPEY
     AKYLKYPQCL HMLELLQYEH FRKELVNAQC AKFIDEQQIL HWQHYSRKRV RLQQALAEQQ
     QQNNTSGK