ID   MD31B_XENLA             Reviewed;         129 AA.
AC   Q6GQA1;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 31-B;
DE   AltName: Full=Mediator complex subunit 31-B;
DE   AltName: Full=Mediator complex subunit soh1-B;
GN   Name=med31-b; Synonyms=soh1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 31 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH72845.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC072845; AAH72845.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001085493.2; NM_001092024.1.
DR   RefSeq; XP_018104615.1; XM_018249126.1.
DR   AlphaFoldDB; Q6GQA1; -.
DR   SMR; Q6GQA1; -.
DR   MaxQB; Q6GQA1; -.
DR   DNASU; 443919; -.
DR   GeneID; 108709359; -.
DR   GeneID; 443919; -.
DR   KEGG; xla:108709359; -.
DR   KEGG; xla:443919; -.
DR   CTD; 443919; -.
DR   Xenbase; XB-GENE-6251530; med31.S.
DR   OMA; KRHRLCM; -.
DR   OrthoDB; 1480492at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 108709359; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   Gene3D; 1.10.10.1340; -; 1.
DR   InterPro; IPR038089; Med31_sf.
DR   InterPro; IPR008831; Mediator_Med31.
DR   PANTHER; PTHR13186; PTHR13186; 1.
DR   Pfam; PF05669; Med31; 1.
PE   2: Evidence at transcript level;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..129
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   31-B"
FT                   /id="PRO_0000305710"
SQ   SEQUENCE   129 AA;  15777 MW;  63C587BC354ECFC8 CRC64;
     MAAAAMEADE QHRIRFQLEL EFVQCLANPN YLNFLAQRGY FKDKSFVNYL KYLLYWKDPE
     YAKYLKYPQC LHMLELLQYE HFRKELVNAQ CAKFIDEQQI LHWQHYSRKR MRMQQALAEQ
     QQQNNTSSK