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MDA2_ARATH
ID   MDA2_ARATH              Reviewed;         211 AA.
AC   F4KF27; Q9FLF2;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Mediator-associated protein 2;
GN   OrderedLocusNames=At5g64680; ORFNames=MUB3.20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA   Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT   features of the regions of 1,456,315 bp covered by nineteen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:41-54(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA   Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA   Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBUNIT.
RX   PubMed=17560376; DOI=10.1016/j.molcel.2007.05.007;
RA   Baeckstroem S., Elfving N., Nilsson R., Wingsle G., Bjoerklund S.;
RT   "Purification of a plant mediator from Arabidopsis thaliana identifies PFT1
RT   as the Med25 subunit.";
RL   Mol. Cell 26:717-729(2007).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19376835; DOI=10.1104/pp.109.138677;
RA   Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA   Grossmann J., Gruissem W., Baginsky S.;
RT   "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT   chloroplast kinase substrates and phosphorylation networks.";
RL   Plant Physiol. 150:889-903(2009).
CC   -!- SUBUNIT: Associated with the Mediator complex.
CC       {ECO:0000269|PubMed:17560376}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=F4KF27-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=F4KF27-2; Sequence=VSP_044126;
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DR   EMBL; AB010076; BAB11435.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED97936.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED97937.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED97938.1; -; Genomic_DNA.
DR   EMBL; AK118987; BAC43563.1; -; mRNA.
DR   EMBL; BT005670; AAO64090.1; -; mRNA.
DR   RefSeq; NP_001154796.1; NM_001161324.1. [F4KF27-1]
DR   RefSeq; NP_201273.1; NM_125864.3. [F4KF27-2]
DR   RefSeq; NP_851270.1; NM_180939.2. [F4KF27-2]
DR   AlphaFoldDB; F4KF27; -.
DR   IntAct; F4KF27; 1.
DR   STRING; 3702.AT5G64680.3; -.
DR   iPTMnet; F4KF27; -.
DR   PaxDb; F4KF27; -.
DR   PRIDE; F4KF27; -.
DR   ProteomicsDB; 250837; -. [F4KF27-1]
DR   EnsemblPlants; AT5G64680.1; AT5G64680.1; AT5G64680. [F4KF27-2]
DR   EnsemblPlants; AT5G64680.2; AT5G64680.2; AT5G64680. [F4KF27-2]
DR   EnsemblPlants; AT5G64680.3; AT5G64680.3; AT5G64680. [F4KF27-1]
DR   GeneID; 836589; -.
DR   Gramene; AT5G64680.1; AT5G64680.1; AT5G64680. [F4KF27-2]
DR   Gramene; AT5G64680.2; AT5G64680.2; AT5G64680. [F4KF27-2]
DR   Gramene; AT5G64680.3; AT5G64680.3; AT5G64680. [F4KF27-1]
DR   KEGG; ath:AT5G64680; -.
DR   Araport; AT5G64680; -.
DR   TAIR; locus:2174834; AT5G64680.
DR   eggNOG; ENOG502RZN5; Eukaryota.
DR   HOGENOM; CLU_070733_1_1_1; -.
DR   InParanoid; F4KF27; -.
DR   OMA; NSHEGKP; -.
DR   OrthoDB; 1407483at2759; -.
DR   PRO; PR:F4KF27; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4KF27; baseline and differential.
DR   Genevisible; F4KF27; AT.
DR   GO; GO:0016592; C:mediator complex; IDA:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR   InterPro; IPR038823; MED2_plant.
DR   PANTHER; PTHR36407; PTHR36407; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..211
FT                   /note="Mediator-associated protein 2"
FT                   /id="PRO_0000419194"
FT   REGION          128..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         173
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19376835"
FT   VAR_SEQ         66..73
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11910074,
FT                   ECO:0000303|PubMed:14593172"
FT                   /id="VSP_044126"
SQ   SEQUENCE   211 AA;  23328 MW;  FFCAB7DDB9A4B760 CRC64;
     MDFDFKVSGD FIVSGAEQLD DTDLTRSDEF WLIQAPLGQF PEIEENTLKI EPDKDGLFGE
     FKDSNAGSLH LCLGAKYDLA SFHSQDAGAE LIIPSEESMI VGKITRRVAL VRYPEPNELL
     QKMKARTQQK LVGSVTNSSK KSSNLTQSSR HKSGTRSSRE KSMFSGFTET PKSPKRKNSE
     SSSGKHRSST STVSGSSERS AKSKKKVKKE E
 
 
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