ID   MDCF_RHIME              Reviewed;         320 AA.
AC   P56949;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Putative malonate transporter;
GN   Name=mdcF; OrderedLocusNames=R01674; ORFNames=SMc00317;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=10858449; DOI=10.1074/jbc.m000844200;
RA   Sohlenkamp C., de Rudder K.E.E., Roehrs V., Lopez-Lara I.M., Geiger O.;
RT   "Cloning and characterization of the gene for phosphatidylcholine
RT   synthase.";
RL   J. Biol. Chem. 275:18919-18925(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the auxin efflux carrier (TC 2.A.69) family.
CC       {ECO:0000305}.
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DR   EMBL; AF155772; AAF27308.1; -; Genomic_DNA.
DR   EMBL; AL591688; CAC46253.1; -; Genomic_DNA.
DR   RefSeq; NP_385780.1; NC_003047.1.
DR   RefSeq; WP_003533213.1; NC_003047.1.
DR   AlphaFoldDB; P56949; -.
DR   STRING; 266834.SMc00317; -.
DR   TCDB; 2.A.69.3.4; the auxin efflux carrier (aec) family.
DR   EnsemblBacteria; CAC46253; CAC46253; SMc00317.
DR   GeneID; 61603143; -.
DR   KEGG; sme:SMc00317; -.
DR   PATRIC; fig|266834.11.peg.3107; -.
DR   eggNOG; COG0679; Bacteria.
DR   HOGENOM; CLU_056175_2_1_5; -.
DR   OMA; LAMWITY; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR004776; Mem_trans.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   Pfam; PF03547; Mem_trans; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..320
FT                   /note="Putative malonate transporter"
FT                   /id="PRO_0000123797"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   320 AA;  34020 MW;  173DAFCA22E11959 CRC64;
     MAEITGLVLP FFGLIFLGYL TARLVDHPGE AMGWLNTFIV YLALPALFFK LVSRTPVEEL
     TRADFILTSV GTTYVVFALI FAIGLFLRRN TVAEATMQGF AGAYGNIGYM GPGLALLALG
     ETAAVPVALI FCFENAAHFT VAPAMMAAAG GSKQKPAVVA LGIARRIAFH PFILSTFAGV
     AAAFLSFEPP LPLQRLIDYL AQAAAPCALF AMGVTLALRP LKRIPAEIGY IVPAKLVLHP
     VLMYLALSLG GAYDPIWVQT AVLLASLPTA TNVFVIGQQY GVWQERASAT ILITTLLSVA
     TVTGLLYLIR SGALPADLFP