MDCG_PSEAE
ID MDCG_PSEAE Reviewed; 210 AA.
AC Q9I6S5;
DT 06-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 06-JUN-2003, sequence version 2.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Phosphoribosyl-dephospho-CoA transferase {ECO:0000255|HAMAP-Rule:MF_00650};
DE EC=2.7.7.66 {ECO:0000255|HAMAP-Rule:MF_00650};
DE AltName: Full=Malonate decarboxylase holo-[acyl-carrier-protein] synthase {ECO:0000255|HAMAP-Rule:MF_00650};
DE Short=Holo-ACP synthase {ECO:0000255|HAMAP-Rule:MF_00650};
GN Name=mdcG {ECO:0000255|HAMAP-Rule:MF_00650}; OrderedLocusNames=PA0213;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme-A to
CC the apo-[acyl-carrier-protein] of the malonate decarboxylase to yield
CC holo-[acyl-carrier-protein]. {ECO:0000255|HAMAP-Rule:MF_00650}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-
CC [malonate decarboxylase ACP] = diphosphate + holo-[malonate
CC decarboxylase ACP]; Xref=Rhea:RHEA:42644, Rhea:RHEA-COMP:10160,
CC Rhea:RHEA-COMP:10161, ChEBI:CHEBI:29999, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:61378, ChEBI:CHEBI:82683; EC=2.7.7.66;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00650};
CC -!- SIMILARITY: Belongs to the MdcG family. {ECO:0000255|HAMAP-
CC Rule:MF_00650}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG03602.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE004091; AAG03602.1; ALT_INIT; Genomic_DNA.
DR PIR; B83619; B83619.
DR RefSeq; NP_248904.1; NC_002516.2.
DR AlphaFoldDB; Q9I6S5; -.
DR STRING; 287.DR97_3170; -.
DR PaxDb; Q9I6S5; -.
DR EnsemblBacteria; AAG03602; AAG03602; PA0213.
DR GeneID; 879254; -.
DR KEGG; pae:PA0213; -.
DR PATRIC; fig|208964.12.peg.222; -.
DR PseudoCAP; PA0213; -.
DR HOGENOM; CLU_111981_0_0_6; -.
DR OMA; PHDLLWG; -.
DR PhylomeDB; Q9I6S5; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00650; Malonate_MdcG; 1.
DR InterPro; IPR017557; Holo-ACP_synthase.
DR Pfam; PF10620; MdcG; 1.
DR TIGRFAMs; TIGR03135; malonate_mdcG; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase; Reference proteome; Transferase.
FT CHAIN 1..210
FT /note="Phosphoribosyl-dephospho-CoA transferase"
FT /id="PRO_0000220294"
FT ACT_SITE 135
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00650"
FT ACT_SITE 137
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00650"
SQ SEQUENCE 210 AA; 23009 MW; 9BEDD0DEAA935F11 CRC64;
MRRRAGPEPH DLLLGMAPAH LPENAPAWVC AALKAGWPVV VRRAPADPAR VAIGVRGLAR
EQRWAGWMPL AAITRRLRPE ALGQREPAML RDLPAWRALR DLRAPLNALG LAWGVTGGAG
FELASGVAVL HPDSDLDLLL RTPRPFPRDD ALRLLQCFEQ CPCRIDLQLQ TPAGGVALRE
WAEGRPRVLA KGSEAPLLLE DPWRIAEVEA
