ID   MDDA_CROS5              Reviewed;         255 AA.
AC   B1WZQ6;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Methanethiol S-methyltransferase {ECO:0000303|PubMed:25807229};
DE            EC=2.1.1.334 {ECO:0000269|PubMed:25807229};
GN   Name=mddA {ECO:0000303|PubMed:25807229};
GN   OrderedLocusNames=cce_1858 {ECO:0000312|EMBL:ACB51208.1};
OS   Crocosphaera subtropica (strain ATCC 51142 / BH68) (Cyanothece sp. (strain
OS   ATCC 51142)).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Aphanothecaceae; Crocosphaera; Crocosphaera subtropica.
OX   NCBI_TaxID=43989;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51142 / BH68;
RX   PubMed=18812508; DOI=10.1073/pnas.0805418105;
RA   Welsh E.A., Liberton M., Stoeckel J., Loh T., Elvitigala T., Wang C.,
RA   Wollam A., Fulton R.S., Clifton S.W., Jacobs J.M., Aurora R., Ghosh B.K.,
RA   Sherman L.A., Smith R.D., Wilson R.K., Pakrasi H.B.;
RT   "The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium
RT   important in the marine nitrogen cycle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:15094-15099(2008).
RN   [2]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RC   STRAIN=ATCC 51142 / BH68;
RX   PubMed=25807229; DOI=10.1038/ncomms7579;
RA   Carrion O., Curson A.R., Kumaresan D., Fu Y., Lang A.S., Mercade E.,
RA   Todd J.D.;
RT   "A novel pathway producing dimethylsulphide in bacteria is widespread in
RT   soil environments.";
RL   Nat. Commun. 6:6579-6579(2015).
CC   -!- FUNCTION: Catalyzes the methylation of methanethiol (MeSH) to yield
CC       dimethylsulphide (DMS). {ECO:0000269|PubMed:25807229}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=methanethiol + S-adenosyl-L-methionine = dimethyl sulfide +
CC         H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:50428,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16007, ChEBI:CHEBI:17437,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:59789; EC=2.1.1.334;
CC         Evidence={ECO:0000269|PubMed:25807229};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the nurim family. {ECO:0000305}.
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DR   EMBL; CP000806; ACB51208.1; -; Genomic_DNA.
DR   RefSeq; WP_009545670.1; NC_010546.1.
DR   AlphaFoldDB; B1WZQ6; -.
DR   STRING; 43989.cce_1858; -.
DR   EnsemblBacteria; ACB51208; ACB51208; cce_1858.
DR   KEGG; cyt:cce_1858; -.
DR   eggNOG; COG2020; Bacteria.
DR   HOGENOM; CLU_084189_0_0_3; -.
DR   OMA; WSIWFPL; -.
DR   OrthoDB; 1734625at2; -.
DR   Proteomes; UP000001203; Chromosome circular.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004671; F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity; IEA:InterPro.
DR   InterPro; IPR007269; ICMT_MeTrfase.
DR   InterPro; IPR033580; Nurim-like.
DR   PANTHER; PTHR31040; PTHR31040; 1.
DR   Pfam; PF04140; ICMT; 1.
PE   1: Evidence at protein level;
KW   Membrane; Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..255
FT                   /note="Methanethiol S-methyltransferase"
FT                   /id="PRO_0000444499"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   255 AA;  29869 MW;  8EF3BAD1921F45DD CRC64;
     MQQQQTLSNS FLSRTFVLLY GVFCYFTFLL TCVYAVGFIG NIFLPKSLDS KSQESLVTAL
     LIDVGLLGIF ALQHSVMARK QFKAWWTRLI PKPMERSTYV LFSSLALMLV FWQWHPIGIT
     IWNFDNLVGQ IIFYSLFALG WVIVLVSTFL INHFDLFGLR QVYLYFEEKE YTPLKFKTPA
     FYQYVRHPLY VGWFLVFWMT PIMTVAHLVF ASVTTIYILV AIQLEEKDLV AIHGEKYENY
     RRQVPMLIPF IGKKS