MDEP_STAA2
ID MDEP_STAA2 Reviewed; 157 AA.
AC A6U3P7;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Multidrug resistance efflux pump SepA;
DE AltName: Full=Antiseptic resistance protein SepA;
DE AltName: Full=Staphylococcal efflux pump A;
GN Name=sepA; OrderedLocusNames=SaurJH1_2237;
OS Staphylococcus aureus (strain JH1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=359787;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JH1;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.;
RT "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus
RT JH1.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in multidrug efflux. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the multidrug resistance efflux pump SepA
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABR53065.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000736; ABR53065.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000636857.1; NC_009632.1.
DR AlphaFoldDB; A6U3P7; -.
DR KEGG; sah:SaurJH1_2237; -.
DR HOGENOM; CLU_151983_0_0_9; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR031396; SepA.
DR Pfam; PF17080; SepA; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..155
FT /note="Multidrug resistance efflux pump SepA"
FT /id="PRO_5000257090"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 157 AA; 18899 MW; 385E73CE8F18B019 CRC64;
MIVNYLKHKF YNLLTTMIVL FIFVLSGAIF LTFLGFGLYG LSRILIYFRL GDFTYNRSMY
DNLLYYGSYI IFGYFIIFAV EHLMDYFRKM LPENAYFRGA TFHLISYTVA TTLFYFIIHL
NYVYINIDFW VIMVIIGFLY VCKLQFYPES KNLNNRK