ID   MDEP_STAA3              Reviewed;         157 AA.
AC   Q2FEW4;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Multidrug resistance efflux pump SepA;
DE   AltName: Full=Antiseptic resistance protein SepA;
DE   AltName: Full=Staphylococcal efflux pump A;
GN   Name=sepA; OrderedLocusNames=SAUSA300_2127;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Involved in multidrug efflux. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the multidrug resistance efflux pump SepA
CC       family. {ECO:0000305}.
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DR   EMBL; CP000255; ABD22513.1; -; Genomic_DNA.
DR   RefSeq; WP_000636857.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FEW4; -.
DR   EnsemblBacteria; ABD22513; ABD22513; SAUSA300_2127.
DR   KEGG; saa:SAUSA300_2127; -.
DR   HOGENOM; CLU_151983_0_0_9; -.
DR   OMA; ISYMVAT; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031396; SepA.
DR   Pfam; PF17080; SepA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..157
FT                   /note="Multidrug resistance efflux pump SepA"
FT                   /id="PRO_0000351494"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   157 AA;  18899 MW;  385E73CE8F18B019 CRC64;
     MIVNYLKHKF YNLLTTMIVL FIFVLSGAIF LTFLGFGLYG LSRILIYFRL GDFTYNRSMY
     DNLLYYGSYI IFGYFIIFAV EHLMDYFRKM LPENAYFRGA TFHLISYTVA TTLFYFIIHL
     NYVYINIDFW VIMVIIGFLY VCKLQFYPES KNLNNRK